Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1K55

OXA 10 class D beta-lactamase at pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0042597	cellular_component	periplasmic space
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	ARG131
A	LYS134
A	TYR135
A	HOH1193

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	THR206
A	ARG250
A	LYS251
A	SO41007
A	HOH1070

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1007

Chain	Residue
A	SER67
A	SER115
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250
A	SO41006
A	HOH1050

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1012

Chain	Residue
A	GLY128
A	GLU129
A	VAL130
A	HOH1048
A	HOH1054
A	HOH1149

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1015

Chain	Residue
A	MET99
A	LYS100
A	GLN101
A	HOH1186

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1016

Chain	Residue
A	ARG160
A	HOH1178

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1038

Chain	Residue
A	GLU195
A	TYR200
A	ILE263
A	HOH1130

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1039

Chain	Residue
A	GLU199
A	GLU227
A	GLU229
A	HOH1136
C	THR107
C	ARG109
C	HOH1068

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1041

Chain	Residue
A	PRO217
A	ASP240
A	ASP242
A	HOH1103
A	HOH1134

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 B 1001

Chain	Residue
B	SER67
B	SER115
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250
B	SO41011
B	HOH1044
B	HOH1147
B	HOH1257

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1011

Chain	Residue
B	THR206
B	ARG250
B	SO41001
B	HOH1147
B	HOH1271

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1021

Chain	Residue
B	ARG131
B	LYS134
B	TYR135
B	HOH1215

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1022

Chain	Residue
B	ARG160
B	HOH1308

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1023

Chain	Residue
B	MET99
B	LYS100
B	GLN101
B	HOH1216
B	HOH1221

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 1033

Chain	Residue
B	ASN29
B	PHE32
B	VAL37
B	ASN38
B	GLY39
B	ASN54
B	HOH1180

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 1037

Chain	Residue
B	PRO217
B	ASP240
B	ASP242
B	HOH1050
B	HOH1072
B	HOH1164
B	HOH1199

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1005

Chain	Residue
B	LYS95
C	SER115
C	LYS205
C	THR206
C	GLY207
C	PHE208
C	ARG250
C	HOH1053

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1019

Chain	Residue
B	LYS152
C	THR213
C	HOH1118

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 1003

Chain	Residue
D	SER67
D	SER115
D	THR206
D	GLY207
D	PHE208
D	ARG250
D	SO41024
D	HOH1081
A	LYS95

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1009

Chain	Residue
B	HOH1245
D	SER181
D	LYS182

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1014

Chain	Residue
D	ARG250
D	LYS251
D	HOH1291
D	HOH1301
D	HOH1308

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1020

Chain	Residue
A	HOH1206
D	LYS152
D	HOH1203
D	HOH1241

site_id	CC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 D 1024

Chain	Residue
D	SER67
D	KCX70
D	LYS70
D	TRP102
D	VAL114
D	SER115
D	ALA116
D	VAL117
D	SO41003
D	HOH1273

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 1034

Chain	Residue
B	ARG109
D	ALA197
D	PRO198
D	GLU199
D	TYR200
D	GLU229
D	HOH1044

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 1035

Chain	Residue
D	TYR200
D	THR255
D	MET258
D	ILE264
D	EDO1036

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 1036

Chain	Residue
D	ILE264
D	EDO1035
D	HOH1311

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 1040

Chain	Residue
A	LYS91
A	HOH1113
D	MET99
D	LYS100
D	GLN101

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
C	PRO65-ILE75
A	PRO65-ILE75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
A	SER67

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
B	SER67

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
C	SER67

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
D	SER67

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)