Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1K44

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001907	biological_process	symbiont-mediated killing of host cell
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006163	biological_process	purine nucleotide metabolic process
A	0006183	biological_process	GTP biosynthetic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
B	0000166	molecular_function	nucleotide binding
B	0001907	biological_process	symbiont-mediated killing of host cell
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004844	molecular_function	uracil DNA N-glycosylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006163	biological_process	purine nucleotide metabolic process
B	0006183	biological_process	GTP biosynthetic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
C	0000166	molecular_function	nucleotide binding
C	0001907	biological_process	symbiont-mediated killing of host cell
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004844	molecular_function	uracil DNA N-glycosylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006163	biological_process	purine nucleotide metabolic process
C	0006183	biological_process	GTP biosynthetic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
D	0000166	molecular_function	nucleotide binding
D	0001907	biological_process	symbiont-mediated killing of host cell
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004844	molecular_function	uracil DNA N-glycosylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006163	biological_process	purine nucleotide metabolic process
D	0006183	biological_process	GTP biosynthetic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006228	biological_process	UTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0009117	biological_process	nucleotide metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
E	0000166	molecular_function	nucleotide binding
E	0001907	biological_process	symbiont-mediated killing of host cell
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0004844	molecular_function	uracil DNA N-glycosylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006163	biological_process	purine nucleotide metabolic process
E	0006183	biological_process	GTP biosynthetic process
E	0006220	biological_process	pyrimidine nucleotide metabolic process
E	0006228	biological_process	UTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0009117	biological_process	nucleotide metabolic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
F	0000166	molecular_function	nucleotide binding
F	0001907	biological_process	symbiont-mediated killing of host cell
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0004844	molecular_function	uracil DNA N-glycosylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006163	biological_process	purine nucleotide metabolic process
F	0006183	biological_process	GTP biosynthetic process
F	0006220	biological_process	pyrimidine nucleotide metabolic process
F	0006228	biological_process	UTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0009117	biological_process	nucleotide metabolic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0046872	molecular_function	metal ion binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
A	LYS10
A	ASN114

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
D	LYS10
D	TYR50

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
E	LYS10
E	TYR50

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
F	LYS10
F	TYR50

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
B	LYS10
B	ASN114

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
C	LYS10
C	ASN114

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
D	LYS10
D	ASN114

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
E	LYS10
E	ASN114

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
F	LYS10
F	ASN114

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
A	LYS10
A	TYR50

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
B	LYS10
B	TYR50

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
C	LYS10
C	TYR50

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)