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1K3Y

Crystal Structure Analysis of human Glutathione S-transferase with S-hexyl glutatione and glycerol at 1.3 Angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004601molecular_functionperoxidase activity
A0004602molecular_functionglutathione peroxidase activity
A0004769molecular_functionsteroid delta-isomerase activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0016740molecular_functiontransferase activity
A0016853molecular_functionisomerase activity
A0030855biological_processepithelial cell differentiation
A0043651biological_processlinoleic acid metabolic process
A0070062cellular_componentextracellular exosome
A0098869biological_processcellular oxidant detoxification
A1901687biological_processglutathione derivative biosynthetic process
B0004364molecular_functionglutathione transferase activity
B0004601molecular_functionperoxidase activity
B0004602molecular_functionglutathione peroxidase activity
B0004769molecular_functionsteroid delta-isomerase activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0016740molecular_functiontransferase activity
B0016853molecular_functionisomerase activity
B0030855biological_processepithelial cell differentiation
B0043651biological_processlinoleic acid metabolic process
B0070062cellular_componentextracellular exosome
B0098869biological_processcellular oxidant detoxification
B1901687biological_processglutathione derivative biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GTX A 5100
ChainResidue
ATYR9
AMET208
APHE220
AGOL3002
AHOH6005
AHOH6062
AHOH6184
AHOH6276
BASP101
BARG131
AARG45
AGLN54
AVAL55
APRO56
AGLN67
ATHR68
ALEU107
AVAL111

site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GTX B 5200
ChainResidue
AASP101
AARG131
AHOH6096
BTYR9
BARG45
BGLN54
BVAL55
BPRO56
BGLN67
BTHR68
BLEU107
BVAL111
BPHE220
BGOL3003
BHOH6004
BHOH6122
BHOH6257
BHOH6336
BHOH6357

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 3001
ChainResidue
ATHR68
AILE96
AGLU97
AALA100
AHIS159
AHOH6105
AHOH6187
AHOH6193

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 3002
ChainResidue
AARG15
AARG69
AGLU104
AGTX5100
AHOH6276
AHOH6576
BGOL3003
BHOH6079

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 3003
ChainResidue
AGOL3002
AHOH6096
BARG15
BARG69
BGLU104
BGTX5200
BHOH6098
BHOH6336

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:16421451, ECO:0000269|PubMed:19618965
ChainResidueDetails
APHE10
AASN46
AVAL55
ATHR68
BPHE10
BASN46
BVAL55
BTHR68

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P80894
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed => ECO:0000250|UniProtKB:P30115
ChainResidueDetails
AGLU3
BGLU3

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P30115
ChainResidueDetails
APRO5
BPRO5

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR9

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR9

224004

PDB entries from 2024-08-21

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