1K32

Crystal structure of the tricorn protease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0008236	molecular_function	serine-type peptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958

Chain	Residue	Details
A	HIS746
B	HIS746
C	HIS746
D	HIS746
E	HIS746
F	HIS746

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958

Chain	Residue	Details
A	SER965
B	SER965
C	SER965
D	SER965
E	SER965
F	SER965

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:11719810

Chain	Residue	Details
A	GLU1023
B	GLU1023
C	GLU1023
D	GLU1023
E	GLU1023
F	GLU1023

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958

Chain	Residue	Details
A	GLY916
B	GLY916
C	GLY916
D	GLY916
E	GLY916
F	GLY916

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:12470958

Chain	Residue	Details
A	GLY993
B	GLY993
C	GLY993
D	GLY993
E	GLY993
F	GLY993

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	SITE: Substrate specificity switch => ECO:0000269|PubMed:11719810

Chain	Residue	Details
A	ASP936
B	ASP936
C	ASP936
D	ASP936
E	ASP936
F	ASP936

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958

Chain	Residue	Details
A	ASP966
B	ASP966
C	ASP966
D	ASP966
E	ASP966
F	ASP966

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 11719810

Chain	Residue	Details
A	SER965
A	HIS746
A	ASP966
A	GLY918

---

site_id	CSA2
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 11719810

Chain	Residue	Details
B	SER965
B	HIS746
B	ASP966
B	GLY918

---

site_id	CSA3
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 11719810

Chain	Residue	Details
C	SER965
C	HIS746
C	ASP966
C	GLY918

---

site_id	CSA4
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 11719810

Chain	Residue	Details
D	SER965
D	HIS746
D	ASP966
D	GLY918

---

site_id	CSA5
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 11719810

Chain	Residue	Details
E	SER965
E	HIS746
E	ASP966
E	GLY918

---

site_id	CSA6
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 11719810

Chain	Residue	Details
F	SER965
F	HIS746
F	ASP966
F	GLY918

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
A	HIS746	proton shuttle (general acid/base)
A	GLY918	electrostatic stabiliser
A	SER965	covalently attached
A	ASP966	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
B	HIS746	proton shuttle (general acid/base)
B	GLY918	electrostatic stabiliser
B	SER965	covalently attached
B	ASP966	electrostatic stabiliser

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
C	HIS746	proton shuttle (general acid/base)
C	GLY918	electrostatic stabiliser
C	SER965	covalently attached
C	ASP966	electrostatic stabiliser

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
D	HIS746	proton shuttle (general acid/base)
D	GLY918	electrostatic stabiliser
D	SER965	covalently attached
D	ASP966	electrostatic stabiliser

---

site_id	MCSA5
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
E	HIS746	proton shuttle (general acid/base)
E	GLY918	electrostatic stabiliser
E	SER965	covalently attached
E	ASP966	electrostatic stabiliser

---

site_id	MCSA6
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
F	HIS746	proton shuttle (general acid/base)
F	GLY918	electrostatic stabiliser
F	SER965	covalently attached
F	ASP966	electrostatic stabiliser

---