1K0W
CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005996 | biological_process | monosaccharide metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008742 | molecular_function | L-ribulose-phosphate 4-epimerase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019323 | biological_process | pentose catabolic process |
| A | 0019324 | biological_process | L-lyxose metabolic process |
| A | 0019568 | biological_process | arabinose catabolic process |
| A | 0019569 | biological_process | L-arabinose catabolic process to xylulose 5-phosphate |
| A | 0019572 | biological_process | L-arabinose catabolic process |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005996 | biological_process | monosaccharide metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008742 | molecular_function | L-ribulose-phosphate 4-epimerase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019323 | biological_process | pentose catabolic process |
| B | 0019324 | biological_process | L-lyxose metabolic process |
| B | 0019568 | biological_process | arabinose catabolic process |
| B | 0019569 | biological_process | L-arabinose catabolic process to xylulose 5-phosphate |
| B | 0019572 | biological_process | L-arabinose catabolic process |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005996 | biological_process | monosaccharide metabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008742 | molecular_function | L-ribulose-phosphate 4-epimerase activity |
| C | 0016832 | molecular_function | aldehyde-lyase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019323 | biological_process | pentose catabolic process |
| C | 0019324 | biological_process | L-lyxose metabolic process |
| C | 0019568 | biological_process | arabinose catabolic process |
| C | 0019569 | biological_process | L-arabinose catabolic process to xylulose 5-phosphate |
| C | 0019572 | biological_process | L-arabinose catabolic process |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0005996 | biological_process | monosaccharide metabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008742 | molecular_function | L-ribulose-phosphate 4-epimerase activity |
| D | 0016832 | molecular_function | aldehyde-lyase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019323 | biological_process | pentose catabolic process |
| D | 0019324 | biological_process | L-lyxose metabolic process |
| D | 0019568 | biological_process | arabinose catabolic process |
| D | 0019569 | biological_process | L-arabinose catabolic process to xylulose 5-phosphate |
| D | 0019572 | biological_process | L-arabinose catabolic process |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005996 | biological_process | monosaccharide metabolic process |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0008742 | molecular_function | L-ribulose-phosphate 4-epimerase activity |
| E | 0016832 | molecular_function | aldehyde-lyase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0019323 | biological_process | pentose catabolic process |
| E | 0019324 | biological_process | L-lyxose metabolic process |
| E | 0019568 | biological_process | arabinose catabolic process |
| E | 0019569 | biological_process | L-arabinose catabolic process to xylulose 5-phosphate |
| E | 0019572 | biological_process | L-arabinose catabolic process |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0005996 | biological_process | monosaccharide metabolic process |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0008742 | molecular_function | L-ribulose-phosphate 4-epimerase activity |
| F | 0016832 | molecular_function | aldehyde-lyase activity |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0019323 | biological_process | pentose catabolic process |
| F | 0019324 | biological_process | L-lyxose metabolic process |
| F | 0019568 | biological_process | arabinose catabolic process |
| F | 0019569 | biological_process | L-arabinose catabolic process to xylulose 5-phosphate |
| F | 0019572 | biological_process | L-arabinose catabolic process |
| F | 0032991 | cellular_component | protein-containing complex |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS95 |
| A | HIS97 |
| A | HIS171 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS95 |
| B | HIS97 |
| B | HIS171 |
| B | HOH388 |
| B | HOH403 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 303 |
| Chain | Residue |
| C | HIS97 |
| C | HIS171 |
| C | HOH389 |
| C | HIS95 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 304 |
| Chain | Residue |
| D | HIS95 |
| D | HIS97 |
| D | HIS171 |
| D | HOH371 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN E 305 |
| Chain | Residue |
| E | HIS95 |
| E | HIS97 |
| E | HIS171 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN F 306 |
| Chain | Residue |
| F | HIS95 |
| F | HIS97 |
| F | HIS171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00989, ECO:0000305|PubMed:11732896 |
| Chain | Residue | Details |
| A | ASN120 | |
| E | TYR229 | |
| F | ASN120 | |
| F | TYR229 | |
| A | TYR229 | |
| B | ASN120 | |
| B | TYR229 | |
| C | ASN120 | |
| C | TYR229 | |
| D | ASN120 | |
| D | TYR229 | |
| E | ASN120 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0AB87, ECO:0000255|HAMAP-Rule:MF_00989 |
| Chain | Residue | Details |
| A | GLY27 | |
| D | GLY27 | |
| D | SER44 | |
| D | SER74 | |
| E | GLY27 | |
| E | SER44 | |
| E | SER74 | |
| F | GLY27 | |
| F | SER44 | |
| F | SER74 | |
| A | SER44 | |
| A | SER74 | |
| B | GLY27 | |
| B | SER44 | |
| B | SER74 | |
| C | GLY27 | |
| C | SER44 | |
| C | SER74 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00989, ECO:0000305|PubMed:10769138, ECO:0000305|PubMed:9548961 |
| Chain | Residue | Details |
| A | ASP76 | |
| B | ASP76 | |
| C | ASP76 | |
| D | ASP76 | |
| E | ASP76 | |
| F | ASP76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00989, ECO:0000269|PubMed:11732895, ECO:0000269|PubMed:11732896, ECO:0000305|PubMed:10769138, ECO:0000305|PubMed:10769139, ECO:0007744|PDB:1JDI, ECO:0007744|PDB:1K0W |
| Chain | Residue | Details |
| A | HIS95 | |
| E | HIS97 | |
| F | HIS95 | |
| F | HIS97 | |
| A | HIS97 | |
| B | HIS95 | |
| B | HIS97 | |
| C | HIS95 | |
| C | HIS97 | |
| D | HIS95 | |
| D | HIS97 | |
| E | HIS95 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00989, ECO:0000269|PubMed:11732895, ECO:0000269|PubMed:11732896, ECO:0000305|PubMed:10769138, ECO:0007744|PDB:1JDI, ECO:0007744|PDB:1K0W |
| Chain | Residue | Details |
| A | HIS171 | |
| B | HIS171 | |
| C | HIS171 | |
| D | HIS171 | |
| E | HIS171 | |
| F | HIS171 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 273 |
| Chain | Residue | Details |
| A | HIS95 | metal ligand |
| A | HIS97 | metal ligand |
| A | ASN120 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS171 | metal ligand |
| A | TYR229 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 273 |
| Chain | Residue | Details |
| B | HIS95 | metal ligand |
| B | HIS97 | metal ligand |
| B | ASN120 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS171 | metal ligand |
| B | TYR229 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 273 |
| Chain | Residue | Details |
| C | HIS95 | metal ligand |
| C | HIS97 | metal ligand |
| C | ASN120 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | HIS171 | metal ligand |
| C | TYR229 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 273 |
| Chain | Residue | Details |
| D | HIS95 | metal ligand |
| D | HIS97 | metal ligand |
| D | ASN120 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | HIS171 | metal ligand |
| D | TYR229 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 273 |
| Chain | Residue | Details |
| E | HIS95 | metal ligand |
| E | HIS97 | metal ligand |
| E | ASN120 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | HIS171 | metal ligand |
| E | TYR229 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 273 |
| Chain | Residue | Details |
| F | HIS95 | metal ligand |
| F | HIS97 | metal ligand |
| F | ASN120 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | HIS171 | metal ligand |
| F | TYR229 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11732895, 10769139, 11732896 |
| Chain | Residue | Details |
| A | ASN120 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11732895, 10769139, 11732896 |
| Chain | Residue | Details |
| B | ASN120 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11732895, 10769139, 11732896 |
| Chain | Residue | Details |
| C | ASN120 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11732895, 10769139, 11732896 |
| Chain | Residue | Details |
| D | ASN120 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11732895, 10769139, 11732896 |
| Chain | Residue | Details |
| E | ASN120 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11732895, 10769139, 11732896 |
| Chain | Residue | Details |
| F | ASN120 |
