1JZ6
E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTO-TETRAZOLE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004565 | molecular_function | beta-galactosidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005990 | biological_process | lactose catabolic process |
| A | 0009341 | cellular_component | beta-galactosidase complex |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0031420 | molecular_function | alkali metal ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0004565 | molecular_function | beta-galactosidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0005990 | biological_process | lactose catabolic process |
| B | 0009341 | cellular_component | beta-galactosidase complex |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0030246 | molecular_function | carbohydrate binding |
| B | 0031420 | molecular_function | alkali metal ion binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0004565 | molecular_function | beta-galactosidase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0005990 | biological_process | lactose catabolic process |
| C | 0009341 | cellular_component | beta-galactosidase complex |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0030246 | molecular_function | carbohydrate binding |
| C | 0031420 | molecular_function | alkali metal ion binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0004565 | molecular_function | beta-galactosidase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0005990 | biological_process | lactose catabolic process |
| D | 0009341 | cellular_component | beta-galactosidase complex |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0030246 | molecular_function | carbohydrate binding |
| D | 0031420 | molecular_function | alkali metal ion binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTZ A 2001 |
| Chain | Residue |
| A | ASP201 |
| A | ASN604 |
| A | TRP999 |
| A | NA3101 |
| A | HOH8517 |
| A | HOH8531 |
| A | HOH8580 |
| A | HIS391 |
| A | ASN460 |
| A | GLU461 |
| A | MET502 |
| A | TYR503 |
| A | GLU537 |
| A | HIS540 |
| A | TRP568 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTZ B 2001 |
| Chain | Residue |
| B | ASP201 |
| B | HIS391 |
| B | ASN460 |
| B | GLU461 |
| B | MET502 |
| B | TYR503 |
| B | GLU537 |
| B | HIS540 |
| B | TRP568 |
| B | ASN604 |
| B | TRP999 |
| B | NA3101 |
| B | HOH8627 |
| B | HOH8641 |
| B | HOH8691 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GTZ C 2001 |
| Chain | Residue |
| C | ASP201 |
| C | HIS391 |
| C | ASN460 |
| C | GLU461 |
| C | MET502 |
| C | TYR503 |
| C | GLU537 |
| C | HIS540 |
| C | TRP568 |
| C | ASN604 |
| C | TRP999 |
| C | NA3101 |
| C | HOH8628 |
| C | HOH8642 |
| C | HOH8691 |
| C | HOH8762 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTZ D 2001 |
| Chain | Residue |
| D | ASP201 |
| D | HIS391 |
| D | ASN460 |
| D | GLU461 |
| D | MET502 |
| D | TYR503 |
| D | GLU537 |
| D | HIS540 |
| D | TRP568 |
| D | PHE601 |
| D | ASN604 |
| D | TRP999 |
| D | NA3101 |
| D | HOH8740 |
| D | HOH8803 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 3001 |
| Chain | Residue |
| A | GLU416 |
| A | HIS418 |
| A | GLU461 |
| A | HOH8517 |
| A | HOH8580 |
| A | HOH8656 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3002 |
| Chain | Residue |
| A | ASP15 |
| A | ASN18 |
| A | VAL21 |
| A | GLN163 |
| A | ASP193 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3005 |
| Chain | Residue |
| A | DMS8406 |
| A | HOH9043 |
| A | HOH9159 |
| A | HOH9160 |
| A | HOH9198 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 3101 |
| Chain | Residue |
| A | ASP201 |
| A | PHE601 |
| A | ASN604 |
| A | GTZ2001 |
| A | HOH8769 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 3102 |
| Chain | Residue |
| A | PHE556 |
| A | TYR559 |
| A | PRO560 |
| A | LEU562 |
| A | HOH8879 |
| A | HOH9032 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 3103 |
| Chain | Residue |
| A | PHE931 |
| A | PRO932 |
| A | LEU967 |
| A | THR970 |
| A | HOH8703 |
| A | HOH9094 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3105 |
| Chain | Residue |
| A | SER647 |
| A | GLU650 |
| A | LEU670 |
| A | DMS8425 |
| A | HOH9105 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 3001 |
| Chain | Residue |
| B | GLU416 |
| B | HIS418 |
| B | GLU461 |
| B | HOH8627 |
| B | HOH8691 |
| B | HOH8766 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 3002 |
| Chain | Residue |
| B | ASP15 |
| B | ASN18 |
| B | VAL21 |
| B | GLN163 |
| B | ASP193 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 3101 |
| Chain | Residue |
| B | ASP201 |
| B | PHE601 |
| B | ASN604 |
| B | GTZ2001 |
| B | HOH8875 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 3102 |
| Chain | Residue |
| B | PHE556 |
| B | TYR559 |
| B | PRO560 |
| B | LEU562 |
| B | HOH9142 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 3103 |
| Chain | Residue |
| B | PHE931 |
| B | PRO932 |
| B | LEU967 |
| B | THR970 |
| B | HOH8811 |
| B | HOH9194 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 3105 |
| Chain | Residue |
| B | SER647 |
| B | GLU650 |
| B | LEU670 |
| B | DMS8425 |
| B | HOH9205 |
| B | HOH9274 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 3001 |
| Chain | Residue |
| C | GLU416 |
| C | HIS418 |
| C | GLU461 |
| C | HOH8628 |
| C | HOH8691 |
| C | HOH8768 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 3002 |
| Chain | Residue |
| C | ASP15 |
| C | ASN18 |
| C | VAL21 |
| C | GLN163 |
| C | ASP193 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 3101 |
| Chain | Residue |
| C | ASP201 |
| C | PHE601 |
| C | ASN604 |
| C | GTZ2001 |
| C | HOH8881 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 3102 |
| Chain | Residue |
| C | PHE556 |
| C | TYR559 |
| C | PRO560 |
| C | LEU562 |
| C | HOH8989 |
| C | HOH9127 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 3105 |
| Chain | Residue |
| C | SER647 |
| C | GLU650 |
| C | LEU670 |
| C | DMS8425 |
| C | HOH9196 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 3001 |
| Chain | Residue |
| D | GLU416 |
| D | HIS418 |
| D | GLU461 |
| D | HOH8740 |
| D | HOH8803 |
| D | HOH8880 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 3002 |
| Chain | Residue |
| D | ASP15 |
| D | ASN18 |
| D | VAL21 |
| D | GLN163 |
| D | ASP193 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 3005 |
| Chain | Residue |
| A | HOH9224 |
| D | HOH9263 |
| D | HOH9369 |
| D | HOH9370 |
| D | HOH9406 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 3101 |
| Chain | Residue |
| D | ASP201 |
| D | PHE601 |
| D | ASN604 |
| D | GTZ2001 |
| D | HOH8990 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 3102 |
| Chain | Residue |
| D | PHE556 |
| D | TYR559 |
| D | PRO560 |
| D | LEU562 |
| D | HOH9101 |
| D | HOH9248 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 3103 |
| Chain | Residue |
| D | PHE931 |
| D | PRO932 |
| D | LEU967 |
| D | MET968 |
| D | THR970 |
| D | HOH8926 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 8401 |
| Chain | Residue |
| A | THR229 |
| A | VAL330 |
| A | GLY331 |
| A | ASN449 |
| A | PRO451 |
| A | HOH8514 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 8402 |
| Chain | Residue |
| A | ARG557 |
| A | HIS622 |
| A | GLN623 |
| A | GLN625 |
| A | GLN628 |
| A | HOH8701 |
| site_id | DC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS A 8403 |
| Chain | Residue |
| A | LYS380 |
| A | ASN383 |
| A | PHE626 |
| A | TYR642 |
| A | TRP708 |
| A | HOH8579 |
| A | HOH8710 |
| A | HOH8789 |
| A | HOH8802 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8404 |
| Chain | Residue |
| A | PRO32 |
| A | PHE33 |
| A | ALA327 |
| A | HOH8890 |
| A | HOH9038 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8405 |
| Chain | Residue |
| A | THR271 |
| A | THR290 |
| A | LEU291 |
| A | ARG292 |
| site_id | DC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 8406 |
| Chain | Residue |
| A | GLU314 |
| A | HIS316 |
| A | GLY320 |
| A | MG3005 |
| A | HOH9070 |
| A | HOH9159 |
| A | HOH9252 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8407 |
| Chain | Residue |
| A | GLU508 |
| A | PRO1001 |
| A | VAL1003 |
| A | HOH8949 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8408 |
| Chain | Residue |
| A | LEU54 |
| A | ASN55 |
| A | PHE127 |
| A | HOH9086 |
| A | HOH9095 |
| site_id | EC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS A 8409 |
| Chain | Residue |
| A | GLU334 |
| A | VAL335 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8410 |
| Chain | Residue |
| A | PRO106 |
| A | PRO115 |
| A | TRP191 |
| A | HOH8758 |
| A | HOH8846 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8411 |
| Chain | Residue |
| A | ILE576 |
| A | TRP585 |
| A | SER586 |
| A | ARG973 |
| A | HOH8604 |
| site_id | EC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 8412 |
| Chain | Residue |
| A | GLU277 |
| A | THR290 |
| A | ARG292 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8414 |
| Chain | Residue |
| A | VAL84 |
| A | VAL85 |
| A | HIS93 |
| A | HOH8922 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8417 |
| Chain | Residue |
| A | PHE231 |
| A | ASN232 |
| A | GLU334 |
| A | HOH9028 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8420 |
| Chain | Residue |
| A | ASP428 |
| A | HOH9277 |
| D | ARG448 |
| D | VAL478 |
| D | HOH9179 |
| site_id | EC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS A 8421 |
| Chain | Residue |
| A | GLY94 |
| A | TYR95 |
| site_id | EC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS A 8425 |
| Chain | Residue |
| A | SER647 |
| A | ASP648 |
| A | ASN649 |
| A | GLU650 |
| A | ASN704 |
| A | MG3105 |
| A | HOH9144 |
| C | GLN1022 |
| C | LYS1023 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 8501 |
| Chain | Residue |
| A | TRP36 |
| A | ASP45 |
| A | ARG46 |
| A | PRO47 |
| A | SER48 |
| A | HOH8956 |
| A | HOH9128 |
| site_id | FC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS A 8504 |
| Chain | Residue |
| A | GLU136 |
| A | HIS216 |
| site_id | FC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS B 8401 |
| Chain | Residue |
| B | THR229 |
| B | VAL330 |
| B | GLY331 |
| B | ASN449 |
| B | PRO451 |
| B | ARG482 |
| B | HOH8624 |
| site_id | FC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8402 |
| Chain | Residue |
| B | ARG557 |
| B | HIS622 |
| B | GLN623 |
| B | GLN628 |
| B | HOH8631 |
| B | HOH8809 |
| site_id | FC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS B 8403 |
| Chain | Residue |
| B | LYS380 |
| B | ASN383 |
| B | PHE626 |
| B | TYR642 |
| B | TRP708 |
| B | HOH8818 |
| B | HOH8886 |
| site_id | FC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8404 |
| Chain | Residue |
| B | PRO32 |
| B | PHE33 |
| B | TRP36 |
| B | ASP45 |
| B | ALA327 |
| B | HOH8992 |
| site_id | FC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS B 8405 |
| Chain | Residue |
| B | THR271 |
| B | LEU291 |
| B | ARG292 |
| site_id | FC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8407 |
| Chain | Residue |
| B | GLU508 |
| B | PRO1001 |
| B | VAL1003 |
| B | HOH8650 |
| B | HOH8846 |
| B | HOH9049 |
| site_id | FC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8408 |
| Chain | Residue |
| B | LEU54 |
| B | ASN55 |
| B | GLU57 |
| B | TRP58 |
| B | LEU125 |
| site_id | GC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8409 |
| Chain | Residue |
| B | GLU334 |
| B | VAL335 |
| B | ARG336 |
| B | HOH8816 |
| B | HOH9070 |
| site_id | GC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8411 |
| Chain | Residue |
| B | ILE576 |
| B | PRO584 |
| B | SER586 |
| B | ARG973 |
| B | HOH8715 |
| site_id | GC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8412 |
| Chain | Residue |
| B | GLY275 |
| B | GLY276 |
| B | VAL289 |
| B | THR290 |
| site_id | GC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS B 8414 |
| Chain | Residue |
| B | VAL84 |
| B | VAL85 |
| B | HIS93 |
| site_id | GC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8416 |
| Chain | Residue |
| B | GLU249 |
| B | LEU250 |
| B | ARG251 |
| B | ASP252 |
| site_id | GC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8417 |
| Chain | Residue |
| B | PHE231 |
| B | ASN232 |
| B | ASP233 |
| B | PHE235 |
| B | GLU334 |
| site_id | GC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 8421 |
| Chain | Residue |
| B | HIS93 |
| B | GLY94 |
| site_id | GC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 8423 |
| Chain | Residue |
| B | TYR962 |
| B | ARG973 |
| site_id | GC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8425 |
| Chain | Residue |
| B | ASP648 |
| B | ASN649 |
| B | GLU650 |
| B | PRO703 |
| B | ASN704 |
| B | MG3105 |
| site_id | HC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8601 |
| Chain | Residue |
| B | ASN294 |
| B | GLU296 |
| B | HOH8611 |
| B | HOH9266 |
| site_id | HC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS C 8401 |
| Chain | Residue |
| C | THR229 |
| C | GLY331 |
| C | ARG448 |
| C | ASN449 |
| C | PRO451 |
| C | HOH8625 |
| site_id | HC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8402 |
| Chain | Residue |
| C | ARG557 |
| C | HIS622 |
| C | GLN628 |
| C | HOH8815 |
| site_id | HC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS C 8403 |
| Chain | Residue |
| C | LYS380 |
| C | ASN383 |
| C | PHE626 |
| C | TYR642 |
| C | TRP708 |
| C | HOH8690 |
| C | HOH8823 |
| site_id | HC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS C 8404 |
| Chain | Residue |
| C | PRO32 |
| C | PHE33 |
| C | TRP36 |
| C | ASP45 |
| C | ARG310 |
| C | ALA327 |
| C | HOH8653 |
| C | HOH8742 |
| C | HOH8997 |
| site_id | HC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8405 |
| Chain | Residue |
| C | THR271 |
| C | LEU291 |
| C | ARG292 |
| site_id | HC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8407 |
| Chain | Residue |
| C | GLU508 |
| C | PRO1001 |
| C | HOH9048 |
| site_id | HC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS C 8409 |
| Chain | Residue |
| C | GLU334 |
| C | ARG336 |
| site_id | HC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 8411 |
| Chain | Residue |
| C | PRO584 |
| C | TRP585 |
| C | SER586 |
| C | ARG973 |
| C | HOH8715 |
| site_id | IC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS C 8412 |
| Chain | Residue |
| C | GLY275 |
| C | GLY276 |
| C | GLU277 |
| C | VAL289 |
| C | THR290 |
| C | ARG292 |
| site_id | IC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8414 |
| Chain | Residue |
| C | VAL84 |
| C | VAL85 |
| C | HIS93 |
| site_id | IC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8415 |
| Chain | Residue |
| C | LYS621 |
| C | ILE714 |
| C | TRP717 |
| C | HOH8935 |
| site_id | IC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 8417 |
| Chain | Residue |
| C | PHE231 |
| C | ASN232 |
| C | PHE235 |
| C | GLU334 |
| C | HOH9123 |
| site_id | IC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8419 |
| Chain | Residue |
| C | PRO106 |
| C | ILE107 |
| C | THR108 |
| site_id | IC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8421 |
| Chain | Residue |
| C | HIS93 |
| C | GLY94 |
| C | TYR95 |
| site_id | IC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8423 |
| Chain | Residue |
| C | TYR926 |
| C | TYR962 |
| C | ARG973 |
| site_id | IC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 8425 |
| Chain | Residue |
| C | SER647 |
| C | ASP648 |
| C | ASN649 |
| C | GLU650 |
| C | MG3105 |
| site_id | IC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8501 |
| Chain | Residue |
| C | ASP45 |
| C | ARG46 |
| C | PRO47 |
| site_id | JC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8504 |
| Chain | Residue |
| C | GLN50 |
| C | SER132 |
| C | TRP133 |
| C | HIS216 |
| site_id | JC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8601 |
| Chain | Residue |
| C | VAL267 |
| C | ASN294 |
| C | GLU296 |
| C | HOH9254 |
| site_id | JC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8602 |
| Chain | Residue |
| C | GLN266 |
| C | VAL267 |
| D | LEU740 |
| site_id | JC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8401 |
| Chain | Residue |
| D | THR229 |
| D | VAL330 |
| D | GLY331 |
| D | ASN449 |
| D | PRO451 |
| D | HOH8737 |
| site_id | JC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8402 |
| Chain | Residue |
| D | ARG557 |
| D | HIS622 |
| D | GLN623 |
| D | GLN628 |
| D | HOH8924 |
| site_id | JC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8403 |
| Chain | Residue |
| D | LYS380 |
| D | ASN383 |
| D | TYR642 |
| D | TRP708 |
| D | HOH8933 |
| site_id | JC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS D 8404 |
| Chain | Residue |
| D | PRO32 |
| D | PHE33 |
| D | TRP36 |
| D | ASP45 |
| D | DMS8501 |
| D | HOH8853 |
| D | HOH9254 |
| site_id | JC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS D 8405 |
| Chain | Residue |
| D | THR271 |
| D | LEU291 |
| D | ARG292 |
| D | HOH9288 |
| site_id | JC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS D 8406 |
| Chain | Residue |
| A | GLU136 |
| D | GLU314 |
| D | HIS316 |
| D | GLY320 |
| site_id | KC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8407 |
| Chain | Residue |
| D | GLU508 |
| D | VAL1003 |
| D | GLN1008 |
| D | HOH8763 |
| D | HOH9164 |
| site_id | KC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8408 |
| Chain | Residue |
| D | LEU54 |
| D | ASN55 |
| D | GLY56 |
| D | GLU57 |
| D | HOH9198 |
| D | HOH9310 |
| site_id | KC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8409 |
| Chain | Residue |
| D | GLU334 |
| D | VAL335 |
| D | ARG336 |
| D | HOH8928 |
| D | HOH8931 |
| D | HOH9180 |
| site_id | KC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8411 |
| Chain | Residue |
| D | PRO584 |
| D | TRP585 |
| D | SER586 |
| D | ARG973 |
| D | HOH8827 |
| site_id | KC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS D 8412 |
| Chain | Residue |
| D | GLY275 |
| D | GLY276 |
| D | GLU277 |
| D | VAL289 |
| D | THR290 |
| D | ARG292 |
| D | HOH9227 |
| site_id | KC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS D 8413 |
| Chain | Residue |
| D | GLY593 |
| D | ASP594 |
| D | THR595 |
| site_id | KC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS D 8414 |
| Chain | Residue |
| D | VAL84 |
| D | VAL85 |
| D | HIS93 |
| site_id | KC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8501 |
| Chain | Residue |
| D | TRP36 |
| D | ASP45 |
| D | DMS8404 |
| D | HOH9170 |
| D | HOH9254 |
| D | HOH9334 |
| site_id | KC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS D 8506 |
| Chain | Residue |
| D | ASN102 |
| D | ASP598 |
| D | VAL795 |
| site_id | LC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS D 8701 |
| Chain | Residue |
| A | GLU136 |
| A | ILE323 |
| A | HOH9133 |
| A | HOH9135 |
| D | GLY320 |
| D | LEU322 |
| D | HOH9365 |
| site_id | LC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8703 |
| Chain | Residue |
| A | HOH9160 |
| D | GLN49 |
| D | ASP130 |
| D | SER132 |
| D | TRP133 |
| D | HOH9367 |
| site_id | LC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8705 |
| Chain | Residue |
| D | TRP133 |
| D | LEU134 |
| D | GLN135 |
| D | GLU136 |
| D | SER174 |
Functional Information from PROSITE/UniProt
| site_id | PS00608 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE |
| Chain | Residue | Details |
| A | ASP447-GLU461 |
| site_id | PS00719 |
| Number of Residues | 26 |
| Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV |
| Chain | Residue | Details |
| A | ASN385-VAL410 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"6420154","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1350782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11045615","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Transition state stabilizer"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for ensuring that an appropriate proportion of lactose is converted to allolactose"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| A | GLU461 | |
| A | GLU537 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| B | GLU461 | |
| B | GLU537 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| C | GLU461 | |
| C | GLU537 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| D | GLU461 | |
| D | GLU537 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| A | TYR503 | |
| A | GLU461 | |
| A | GLU537 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| B | TYR503 | |
| B | GLU461 | |
| B | GLU537 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| C | TYR503 | |
| C | GLU461 | |
| C | GLU537 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bgl |
| Chain | Residue | Details |
| D | TYR503 | |
| D | GLU461 | |
| D | GLU537 |
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| A | ASP201 | |
| A | ASN604 | |
| A | HIS357 | |
| A | HIS391 | |
| A | GLU416 | |
| A | HIS418 | |
| A | GLU461 | |
| A | GLU537 | |
| A | ASN597 | |
| A | PHE601 |
| site_id | MCSA2 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| B | ASP201 | |
| B | ASN604 | |
| B | HIS357 | |
| B | HIS391 | |
| B | GLU416 | |
| B | HIS418 | |
| B | GLU461 | |
| B | GLU537 | |
| B | ASN597 | |
| B | PHE601 |
| site_id | MCSA3 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| C | ASP201 | |
| C | ASN604 | |
| C | HIS357 | |
| C | HIS391 | |
| C | GLU416 | |
| C | HIS418 | |
| C | GLU461 | |
| C | GLU537 | |
| C | ASN597 | |
| C | PHE601 |
| site_id | MCSA4 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| D | ASP201 | |
| D | ASN604 | |
| D | HIS357 | |
| D | HIS391 | |
| D | GLU416 | |
| D | HIS418 | |
| D | GLU461 | |
| D | GLU537 | |
| D | ASN597 | |
| D | PHE601 |
