1JY1

CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055

Chain	Residue	Details
A	HIS263

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055

Chain	Residue	Details
A	HIS493

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12470949

Chain	Residue	Details
A	LYS265
A	LYS495

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:12470949

Chain	Residue	Details
A	SER518

---