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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1JXQ

Structure of cleaved, CARD domain deleted Caspase-9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR CHAIN F OF BENZOXYCARBONYL-VAL-ALA-ASP-FLUOROMETHYL KETONE INHIBITOR

Chain	Residue
C	ARG179
C	HIS237
C	GLN283
C	LYS290
C	SER339
C	TRP340
C	ARG341

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR CHAIN E OF BENZOXYCARBONYL-VAL-ALA-ASP-FLUOROMETHYL KETONE INHIBITOR

Chain	Residue
A	LYS290
A	SER339
A	TRP340
A	ARG341
E	HOH94
A	ARG179
A	HIS237

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HgaldCcvVvILSHG

Chain	Residue	Details
A	HIS224-GLY238

site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKLFFIQACGG

Chain	Residue	Details
A	LYS276-GLY287

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS237
A	CYS285
B	HIS237
B	CYS285
C	HIS237
C	CYS285
D	HIS237
D	CYS285

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269\|PubMed:15657060

Chain	Residue	Details
A	TYR153
B	TYR153
C	TYR153
D	TYR153

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	SER296
B	SER287
C	SER296
D	SER287

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER296
B	SER287
C	SER296
D	SER287

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER296
B	SER287
C	SER296
D	SER287

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269\|PubMed:35338844, ECO:0000269\|PubMed:35446120

Chain	Residue	Details
A	ARG341
B	ARG341
C	ARG341
D	ARG341

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
A	GLY238
A	ARG177
A	CYS285
A	HIS237

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
B	CYS285
B	HIS237
B	GLY238

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
C	CYS285
C	HIS237
C	GLY238

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
D	CYS285
D	HIS237
D	GLY238

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
B	GLY238
B	ARG177
B	CYS285
B	HIS237

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
C	GLY238
C	ARG177
C	CYS285
C	HIS237

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
D	GLY238
D	ARG177
D	CYS285
D	HIS237

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
A	ARG177
A	CYS285
A	HIS237
A	GLY275

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
B	ARG177
B	CYS285
B	HIS237
B	GLY275

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
C	ARG177
C	CYS285
C	HIS237
C	GLY275

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
D	ARG177
D	CYS285
D	HIS237
D	GLY275

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
A	CYS285
A	HIS237
A	GLY238

site_id	MCSA1
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
A	ARG177	electrostatic stabiliser
A	HIS237	proton acceptor, proton donor
A	GLY238	electrostatic stabiliser
A	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
B	ARG177	electrostatic stabiliser
B	HIS237	proton acceptor, proton donor
B	GLY238	electrostatic stabiliser
B	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
C	ARG177	electrostatic stabiliser
C	HIS237	proton acceptor, proton donor
C	GLY238	electrostatic stabiliser
C	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
D	ARG177	electrostatic stabiliser
D	HIS237	proton acceptor, proton donor
D	GLY238	electrostatic stabiliser
D	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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PDB entries from 2024-07-17

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