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1JX4

Crystal Structure of a Y-family DNA Polymerase in a Ternary Complex with DNA Substrates and an Incoming Nucleotide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005737cellular_componentcytoplasm
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0006281biological_processDNA repair
A0006974biological_processDNA damage response
A0034061molecular_functionDNA polymerase activity
A0042276biological_processerror-prone translesion synthesis
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 4001
ChainResidue
AASP7
APHE8
AASP105
AADI1014
AHOH4017

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 4002
ChainResidue
PHOH17
PHOH19
AALA181
AILE186
AHOH4003
AHOH4174

site_idAC3
Number of Residues24
DetailsBINDING SITE FOR RESIDUE ADI A 1014
ChainResidue
AASP7
APHE8
ATYR10
APHE11
ATYR12
AALA44
ATHR45
AARG51
AALA57
AMSE76
AASP105
ALYS159
ACA4001
AHOH4004
AHOH4074
AHOH4113
AHOH4124
AHOH4128
AHOH4159
AHOH4184
AHOH4294
PDA13
TDT5
TDT6

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
AGLU106

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AASP7
AASP105

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Substrate discrimination
ChainResidueDetails
ATYR12

227561

PDB entries from 2024-11-20

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