1JX1
Chalcone Isomerase--T48A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009813 | biological_process | flavonoid biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016872 | molecular_function | intramolecular lyase activity |
| A | 0045430 | molecular_function | chalcone isomerase activity |
| B | 0009813 | biological_process | flavonoid biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016872 | molecular_function | intramolecular lyase activity |
| B | 0045430 | molecular_function | chalcone isomerase activity |
| C | 0009813 | biological_process | flavonoid biosynthetic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0016872 | molecular_function | intramolecular lyase activity |
| C | 0045430 | molecular_function | chalcone isomerase activity |
| D | 0009813 | biological_process | flavonoid biosynthetic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0016872 | molecular_function | intramolecular lyase activity |
| D | 0045430 | molecular_function | chalcone isomerase activity |
| E | 0009813 | biological_process | flavonoid biosynthetic process |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0016872 | molecular_function | intramolecular lyase activity |
| E | 0045430 | molecular_function | chalcone isomerase activity |
| F | 0009813 | biological_process | flavonoid biosynthetic process |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0016872 | molecular_function | intramolecular lyase activity |
| F | 0045430 | molecular_function | chalcone isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 601 |
| Chain | Residue |
| B | ARG99 |
| C | ILE45 |
| C | LYS46 |
| C | ARG99 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| F | HOH293 |
| B | ASP167 |
| B | SER169 |
| F | GLU215 |
| F | HOH239 |
| F | HOH259 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 603 |
| Chain | Residue |
| C | ARG36 |
| C | VAL197 |
| C | SER198 |
| C | HOH787 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DFV C 701 |
| Chain | Residue |
| C | ARG36 |
| C | LEU38 |
| C | PHE47 |
| C | ALA48 |
| C | ILE50 |
| C | TYR106 |
| C | ARG108 |
| C | THR190 |
| C | MET191 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA48 | |
| D | ALA48 | |
| D | ASN113 | |
| D | THR190 | |
| E | ALA48 | |
| E | ASN113 | |
| E | THR190 | |
| F | ALA48 | |
| F | ASN113 | |
| F | THR190 | |
| A | ASN113 | |
| A | THR190 | |
| B | ALA48 | |
| B | ASN113 | |
| B | THR190 | |
| C | ALA48 | |
| C | ASN113 | |
| C | THR190 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Important for catalytic activity |
| Chain | Residue | Details |
| A | TYR106 | |
| B | TYR106 | |
| C | TYR106 | |
| D | TYR106 | |
| E | TYR106 | |
| F | TYR106 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eyp |
| Chain | Residue | Details |
| A | ASN113 | |
| A | ALA48 | |
| A | TYR106 | |
| A | THR190 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eyp |
| Chain | Residue | Details |
| B | ASN113 | |
| B | ALA48 | |
| B | TYR106 | |
| B | THR190 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eyp |
| Chain | Residue | Details |
| C | ASN113 | |
| C | ALA48 | |
| C | TYR106 | |
| C | THR190 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eyp |
| Chain | Residue | Details |
| D | ASN113 | |
| D | ALA48 | |
| D | TYR106 | |
| D | THR190 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eyp |
| Chain | Residue | Details |
| E | ASN113 | |
| E | ALA48 | |
| E | TYR106 | |
| E | THR190 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eyp |
| Chain | Residue | Details |
| F | ASN113 | |
| F | ALA48 | |
| F | TYR106 | |
| F | THR190 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 196 |
| Chain | Residue | Details |
| A | ARG36 | |
| A | ALA48 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS97 | modifies pKa |
| A | TYR106 | activator, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 196 |
| Chain | Residue | Details |
| B | ARG36 | |
| B | ALA48 | electrostatic stabiliser, hydrogen bond donor |
| B | LYS97 | modifies pKa |
| B | TYR106 | activator, hydrogen bond donor |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 196 |
| Chain | Residue | Details |
| C | ARG36 | |
| C | ALA48 | electrostatic stabiliser, hydrogen bond donor |
| C | LYS97 | modifies pKa |
| C | TYR106 | activator, hydrogen bond donor |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 196 |
| Chain | Residue | Details |
| D | ARG36 | |
| D | ALA48 | electrostatic stabiliser, hydrogen bond donor |
| D | LYS97 | modifies pKa |
| D | TYR106 | activator, hydrogen bond donor |
| site_id | MCSA5 |
| Number of Residues | 4 |
| Details | M-CSA 196 |
| Chain | Residue | Details |
| E | ARG36 | |
| E | ALA48 | electrostatic stabiliser, hydrogen bond donor |
| E | LYS97 | modifies pKa |
| E | TYR106 | activator, hydrogen bond donor |
| site_id | MCSA6 |
| Number of Residues | 4 |
| Details | M-CSA 196 |
| Chain | Residue | Details |
| F | ARG36 | |
| F | ALA48 | electrostatic stabiliser, hydrogen bond donor |
| F | LYS97 | modifies pKa |
| F | TYR106 | activator, hydrogen bond donor |
