1JWX

Chalcone Synthase--F215S mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009058	biological_process	biosynthetic process
A	0009715	biological_process	chalcone biosynthetic process
A	0009813	biological_process	flavonoid biosynthetic process
A	0016210	molecular_function	naringenin-chalcone synthase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030639	biological_process	polyketide biosynthetic process
A	0102128	molecular_function	chalcone synthase activity

Functional Information from PROSITE/UniProt

site_id	PS00441
Number of Residues	17
Details	CHALCONE_SYNTH Chalcone and stilbene synthases active site. RYmMyQqGCFAGGTvLR

Chain	Residue	Details
A	ARG156-ARG172

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000305

Chain	Residue	Details
A	CSD164

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	GLY216
A	LYS55

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10426957

Chain	Residue	Details
A	THR197

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10426957, ECO:0000269|PubMed:10653632

Chain	Residue	Details
A	ALA308

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 355

Chain	Residue	Details
A	CSD164	activator, covalently attached, nucleofuge, nucleophile
A	SER215	electrostatic destabiliser, polar/non-polar interaction
A	HIS303	electrostatic stabiliser, hydrogen bond donor
A	ASN336	electrostatic stabiliser, hydrogen bond donor

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