1JVG
CRYSTAL STRUCTURE OF HUMAN AGX2 COMPLEXED WITH UDPGALNAC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0003977 | molecular_function | UDP-N-acetylglucosamine diphosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006048 | biological_process | UDP-N-acetylglucosamine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045087 | biological_process | innate immune response |
| A | 0052630 | molecular_function | UDP-N-acetylgalactosamine diphosphorylase activity |
| A | 0070569 | molecular_function | uridylyltransferase activity |
| A | 0140374 | biological_process | antiviral innate immune response |
| A | 0141090 | molecular_function | protein serine pyrophosphorylase activity |
| B | 0002376 | biological_process | immune system process |
| B | 0003977 | molecular_function | UDP-N-acetylglucosamine diphosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006048 | biological_process | UDP-N-acetylglucosamine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045087 | biological_process | innate immune response |
| B | 0052630 | molecular_function | UDP-N-acetylgalactosamine diphosphorylase activity |
| B | 0070569 | molecular_function | uridylyltransferase activity |
| B | 0140374 | biological_process | antiviral innate immune response |
| B | 0141090 | molecular_function | protein serine pyrophosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE UD2 A 1901 |
| Chain | Residue |
| A | LEU108 |
| A | VAL252 |
| A | GLY290 |
| A | GLU303 |
| A | TYR304 |
| A | ASN327 |
| A | ILE328 |
| A | ALA329 |
| A | PHE381 |
| A | PHE383 |
| A | LYS407 |
| A | GLY110 |
| A | HOH1925 |
| A | HOH1957 |
| A | HOH1996 |
| A | HOH2046 |
| A | HOH2047 |
| A | HOH2049 |
| B | ARG453 |
| A | GLY111 |
| A | MET165 |
| A | GLN196 |
| A | PRO220 |
| A | GLY222 |
| A | ASN223 |
| A | CYS251 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UD2 B 1902 |
| Chain | Residue |
| A | ARG453 |
| B | LEU108 |
| B | GLY110 |
| B | GLY111 |
| B | MET165 |
| B | GLN196 |
| B | PRO220 |
| B | GLY222 |
| B | ASN223 |
| B | CYS251 |
| B | VAL252 |
| B | GLY290 |
| B | GLU303 |
| B | TYR304 |
| B | ASN327 |
| B | ILE328 |
| B | ALA329 |
| B | PHE383 |
| B | LYS407 |
| B | HOH1914 |
| B | HOH1936 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11707391","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JVD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11707391","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11707391","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JVD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1JV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JVD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
