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1JTH

Crystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the SNARE region of syntaxin 1a

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0005249molecular_functionvoltage-gated potassium channel activity
A0017075molecular_functionsyntaxin-1 binding
B0005484molecular_functionSNAP receptor activity
B0006886biological_processintracellular protein transport
B0016020cellular_componentmembrane
C0000149molecular_functionSNARE binding
C0005249molecular_functionvoltage-gated potassium channel activity
C0017075molecular_functionsyntaxin-1 binding
D0005484molecular_functionSNAP receptor activity
D0006886biological_processintracellular protein transport
D0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00914
Number of Residues40
DetailsSYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V
ChainResidueDetails
BARG198-VAL237

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C) => ECO:0000269|PubMed:7737992
ChainResidueDetails
BLYS253
DLYS253

site_idSWS_FT_FI2
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q16623
ChainResidueDetails
BLYS252
BLYS253
BLYS256
DLYS252
DLYS253
DLYS256

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PDB entries from 2024-11-06

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