1JRQ
X-ray Structure Analysis of the Role of the Conserved Tyrosine-369 in Active Site of E. coli Amine Oxidase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005507 | molecular_function | copper ion binding |
A | 0005509 | molecular_function | calcium ion binding |
A | 0006559 | biological_process | L-phenylalanine catabolic process |
A | 0008131 | molecular_function | primary methylamine oxidase activity |
A | 0009308 | biological_process | amine metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016641 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
A | 0019607 | biological_process | phenylethylamine catabolic process |
A | 0042597 | cellular_component | periplasmic space |
A | 0046872 | molecular_function | metal ion binding |
A | 0048038 | molecular_function | quinone binding |
B | 0005507 | molecular_function | copper ion binding |
B | 0005509 | molecular_function | calcium ion binding |
B | 0006559 | biological_process | L-phenylalanine catabolic process |
B | 0008131 | molecular_function | primary methylamine oxidase activity |
B | 0009308 | biological_process | amine metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016641 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
B | 0019607 | biological_process | phenylethylamine catabolic process |
B | 0042597 | cellular_component | periplasmic space |
B | 0046872 | molecular_function | metal ion binding |
B | 0048038 | molecular_function | quinone binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CU A 801 |
Chain | Residue |
A | HIS524 |
A | HIS526 |
A | HIS689 |
A | HOH1216 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CA A 802 |
Chain | Residue |
A | ALA679 |
A | HOH948 |
A | LYS133 |
A | ASP533 |
A | LEU534 |
A | ASP535 |
A | ASP678 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 803 |
Chain | Residue |
A | GLU573 |
A | TYR667 |
A | GLU672 |
A | HOH974 |
A | HOH979 |
A | HOH1523 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CU B 801 |
Chain | Residue |
B | HIS524 |
B | HIS526 |
B | HIS689 |
B | HOH1017 |
B | HOH1201 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 802 |
Chain | Residue |
B | ASP533 |
B | LEU534 |
B | ASP535 |
B | ASP678 |
B | ALA679 |
B | HOH981 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 803 |
Chain | Residue |
B | GLU573 |
B | TYR667 |
B | GLU672 |
B | HOH1007 |
B | HOH1012 |
Functional Information from PROSITE/UniProt
site_id | PS01164 |
Number of Residues | 14 |
Details | COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. LVVrwisTvgNYDY |
Chain | Residue | Details |
A | LEU455-TYR468 |
site_id | PS01165 |
Number of Residues | 14 |
Details | COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TtGttHVaraEEwP |
Chain | Residue | Details |
A | THR684-PRO697 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 42 |
Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"10387067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9048544","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OAC","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Active site: {"description":"Schiff-base intermediate with substrate; via topaquinone","evidences":[{"source":"PubMed","id":"10387067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OAC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WOF","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 22 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"10576737","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Z","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"10387067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10576737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9048544","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OAC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SPU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WOF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WOH","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q43077","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"10387067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10576737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9048544","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OAC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SPU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WOH","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"10387067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10576737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9048544","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OAC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SPU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGQ","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"10576737","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1D6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OAC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGQ","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | Binding site: {} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | Modified residue: {"description":"2',4',5'-topaquinone","evidences":[{"source":"PubMed","id":"10387067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QAL","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1oac |
Chain | Residue | Details |
A | ASP383 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1oac |
Chain | Residue | Details |
B | ASP383 |
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 864 |
Chain | Residue | Details |
A | PHE369 | electrostatic stabiliser |
A | ASP383 | proton shuttle (general acid/base) |
A | TPQ466 | covalent catalysis |
A | TYR528 | metal ligand |
A | PHE530 | metal ligand |
A | ALA693 | metal ligand |
site_id | MCSA2 |
Number of Residues | 6 |
Details | M-CSA 864 |
Chain | Residue | Details |
B | PHE369 | electrostatic stabiliser |
B | ASP383 | proton shuttle (general acid/base) |
B | TPQ466 | covalent catalysis |
B | TYR528 | metal ligand |
B | PHE530 | metal ligand |
B | ALA693 | metal ligand |