1JQP
dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001913 | biological_process | T cell mediated cytotoxicity |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005813 | cellular_component | centrosome |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0016505 | molecular_function | peptidase activator activity involved in apoptotic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019902 | molecular_function | phosphatase binding |
| A | 0031404 | molecular_function | chloride ion binding |
| A | 0031642 | biological_process | negative regulation of myelination |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| A | 1903052 | biological_process | positive regulation of proteolysis involved in protein catabolic process |
| A | 1903980 | biological_process | positive regulation of microglial cell activation |
| A | 2001235 | biological_process | positive regulation of apoptotic signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QEsCGSCYSfAS |
| Chain | Residue | Details |
| A | GLN227-SER238 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. TNHAVLLVGYG |
| Chain | Residue | Details |
| A | THR378-GLY388 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgsqWGesGYFrI |
| Chain | Residue | Details |
| A | TYR397-ILE416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088 |
| Chain | Residue | Details |
| A | CYS233 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089 |
| Chain | Residue | Details |
| A | HIS380 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 |
| Chain | Residue | Details |
| A | ASN402 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P53634 |
| Chain | Residue | Details |
| A | PHE277 | |
| A | TYR279 | |
| A | TYR322 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11602245 |
| Chain | Residue | Details |
| A | ASN5 | |
| A | ASN251 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN29 | |
| A | ASN120 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS233 | |
| A | HIS380 | |
| A | ASN402 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | HIS380 | |
| A | CYS233 | |
| A | GLN227 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | HIS380 | |
| A | ASN402 | |
| A | GLN227 |
