1JQD
Crystal Structure Analysis of Human Histamine Methyltransferase (Thr105 Polymorphic Variant) Complexed with AdoHcy and Histamine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001692 | biological_process | histamine metabolic process |
A | 0001695 | biological_process | histamine catabolic process |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005813 | cellular_component | centrosome |
A | 0005829 | cellular_component | cytosol |
A | 0006548 | biological_process | L-histidine catabolic process |
A | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008170 | molecular_function | N-methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0046539 | molecular_function | histamine N-methyltransferase activity |
A | 0070062 | cellular_component | extracellular exosome |
B | 0001692 | biological_process | histamine metabolic process |
B | 0001695 | biological_process | histamine catabolic process |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005813 | cellular_component | centrosome |
B | 0005829 | cellular_component | cytosol |
B | 0006548 | biological_process | L-histidine catabolic process |
B | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0008170 | molecular_function | N-methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0046539 | molecular_function | histamine N-methyltransferase activity |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE SAH A 400 |
Chain | Residue |
A | GLY60 |
A | GLN143 |
A | MET144 |
A | TYR147 |
A | HOH631 |
A | HOH646 |
A | HOH773 |
A | HOH774 |
A | HOH775 |
A | HOH776 |
A | GLY62 |
A | ILE66 |
A | GLU89 |
A | PRO90 |
A | GLN94 |
A | THR119 |
A | SER120 |
A | ILE142 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE SAH B 401 |
Chain | Residue |
B | GLY60 |
B | GLY62 |
B | ILE66 |
B | GLU89 |
B | PRO90 |
B | GLN94 |
B | THR119 |
B | SER120 |
B | ILE142 |
B | GLN143 |
B | MET144 |
B | TYR147 |
B | HOH624 |
B | HOH722 |
B | HOH723 |
B | HOH724 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE HSM A 600 |
Chain | Residue |
A | PHE22 |
A | GLU28 |
A | GLN143 |
A | VAL173 |
A | ASN283 |
A | HOH779 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE HSM B 601 |
Chain | Residue |
B | PHE22 |
B | GLU28 |
B | GLN143 |
B | TYR146 |
B | VAL173 |
B | TRP179 |
B | PHE243 |
B | ASN283 |
B | LEU285 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU28 | |
B | GLU89 | |
B | GLN94 | |
B | SER120 | |
B | ILE142 | |
B | ASN283 | |
A | GLY60 | |
A | GLU89 | |
A | GLN94 | |
A | SER120 | |
A | ILE142 | |
A | ASN283 | |
B | GLU28 | |
B | GLY60 |