1JPV

Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0006218	biological_process	uridine catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0006218	biological_process	uridine catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006152	biological_process	purine nucleoside catabolic process
C	0006218	biological_process	uridine catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1250

Chain	Residue
A	GLY21
A	ARG43
A	ARG86
A	GLY88
A	THR89
A	HOH535

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 2250

Chain	Residue
B	GLY88
B	THR89
B	HOH510
B	HOH523
C	ARG43
B	GLY21
B	ARG86
B	TYR87

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 3250

Chain	Residue
B	ARG43
C	GLY21
C	ARG86
C	GLY88
C	THR89

---

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. ThGIGgPSiAIvleEL

Chain	Residue	Details
A	THR61-LEU76

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:11489901

Chain	Residue	Details
A	HIS5
B	HIS5
C	HIS5

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: in other chain => ECO:0000269|PubMed:11489901, ECO:0007744|PDB:1JDS, ECO:0007744|PDB:1JE0

Chain	Residue	Details
A	GLY21
A	ARG25
A	ARG86
B	GLY21
B	ARG25
B	ARG86
C	GLY21
C	ARG25
C	ARG86

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:11489901, ECO:0007744|PDB:1JE0

Chain	Residue	Details
A	ARG43
B	ARG43
C	ARG43

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: in other chain => ECO:0000269|PubMed:11489901

Chain	Residue	Details
A	GLU163
A	SER204
B	GLU163
B	SER204
C	GLU163
C	SER204

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: in other chain => ECO:0000269|PubMed:11489901, ECO:0007744|PDB:1JDT, ECO:0007744|PDB:1JE1

Chain	Residue	Details
A	GLU180
B	GLU180
C	GLU180

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