1JPK
Gly156Asp mutant of Human UroD, human uroporphyrinogen III decarboxylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004853 | molecular_function | uroporphyrinogen decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006778 | biological_process | porphyrin-containing compound metabolic process |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006784 | biological_process | heme A biosynthetic process |
| A | 0006785 | biological_process | heme B biosynthetic process |
| A | 0006787 | biological_process | porphyrin-containing compound catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0042168 | biological_process | heme metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00906 |
| Number of Residues | 10 |
| Details | UROD_1 Uroporphyrinogen decarboxylase signature 1. PVWCMRQAGR |
| Chain | Residue | Details |
| A | PRO32-ARG41 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14633982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R3Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14633982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R3Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14633982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R3S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14633982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R3Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14633982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R3W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"14633982","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1uro |
| Chain | Residue | Details |
| A | TYR164 | |
| A | ASP86 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 914 |
| Chain | Residue | Details |
| A | ARG37 | proton shuttle (general acid/base) |
| A | ARG41 | electrostatic stabiliser |
| A | ARG50 | proton shuttle (general acid/base) |
| A | ASP86 | enhance reactivity, modifies pKa, transition state stabiliser |
| A | TYR164 | electrostatic stabiliser |
