Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005542 | molecular_function | folic acid binding |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0031427 | biological_process | response to methotrexate |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0046677 | biological_process | response to antibiotic |
A | 0050661 | molecular_function | NADP binding |
A | 0051870 | molecular_function | methotrexate binding |
A | 0051871 | molecular_function | dihydrofolic acid binding |
A | 0070401 | molecular_function | NADP+ binding |
A | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 163 |
Chain | Residue |
A | GLY43 |
A | HIS45 |
A | THR46 |
A | GLY96 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CA A 164 |
Chain | Residue |
A | HOH246 |
A | HOH266 |
A | HOH432 |
A | GLU17 |
A | ASN18 |
A | MET20 |
A | TRP22 |
A | EOH174 |
site_id | AC3 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE FFO A 161 |
Chain | Residue |
A | ILE5 |
A | ALA6 |
A | ALA7 |
A | GLY15 |
A | MET16 |
A | GLU17 |
A | ASP27 |
A | PHE31 |
A | LYS32 |
A | ILE50 |
A | ARG57 |
A | ILE94 |
A | TYR100 |
A | THR113 |
A | HOH206 |
A | HOH212 |
A | HOH229 |
A | HOH263 |
A | HOH322 |
A | HOH352 |
A | HOH377 |
A | HOH384 |
A | HOH416 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EOH A 171 |
Chain | Residue |
A | LYS76 |
A | HOH213 |
A | HOH402 |
A | HOH403 |
A | HOH420 |
A | HOH442 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EOH A 173 |
Chain | Residue |
A | ARG52 |
A | PRO53 |
A | PRO55 |
A | HOH460 |
site_id | AC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EOH A 174 |
Chain | Residue |
A | ASN23 |
A | ASP87 |
A | VAL88 |
A | CA164 |
A | HOH246 |
A | HOH266 |
A | HOH432 |
A | HOH440 |
A | HOH477 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
Chain | Residue | Details |
A | VAL13-THR35 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ILE5 | |
A | ASP27 | |
A | ARG52 | |
A | ARG57 | |
A | THR113 | |
Chain | Residue | Details |
A | ALA7 | |
A | VAL13 | |
A | HIS45 | |
A | SER63 | |
A | LYS76 | |
A | GLY95 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1ra2 |
Chain | Residue | Details |
A | LEU54 | |
A | LEU28 | |
A | PHE31 | |
A | ASP27 | |
A | ILE5 | |
A | MET20 | |
A | ILE94 | |