1JL2
Crystal structure of TCEO RNase H-a chimera combining the folding core from T. thermophilus RNase H and the remaining region of E. coli RNase H
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 163 |
| Chain | Residue | Details |
| A | ASP10 | metal ligand |
| A | GLY11 | metal ligand |
| A | GLU48 | increase acidity, increase basicity, unknown |
| A | ASP70 | metal ligand |
| A | HIS125 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, unknown |
| A | ASP135 | increase acidity, metal ligand, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 163 |
| Chain | Residue | Details |
| B | ASP10 | metal ligand |
| B | GLY11 | metal ligand |
| B | GLU48 | increase acidity, increase basicity, unknown |
| B | ASP70 | metal ligand |
| B | HIS125 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, unknown |
| B | ASP135 | increase acidity, metal ligand, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 163 |
| Chain | Residue | Details |
| C | ASP10 | metal ligand |
| C | GLY11 | metal ligand |
| C | GLU48 | increase acidity, increase basicity, unknown |
| C | ASP70 | metal ligand |
| C | HIS125 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, unknown |
| C | ASP135 | increase acidity, metal ligand, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 163 |
| Chain | Residue | Details |
| D | ASP10 | metal ligand |
| D | GLY11 | metal ligand |
| D | GLU48 | increase acidity, increase basicity, unknown |
| D | ASP70 | metal ligand |
| D | HIS125 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, unknown |
| D | ASP135 | increase acidity, metal ligand, proton acceptor, proton donor |
