Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1JJK

Selenomethionine Substitution of Orotidine-5'-monophosphate Decarboxylase from E. coli Causes a Change in Crystal Contacts and Space Group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0015949	biological_process	nucleobase-containing small molecule interconversion
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0015949	biological_process	nucleobase-containing small molecule interconversion
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0015949	biological_process	nucleobase-containing small molecule interconversion
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0015949	biological_process	nucleobase-containing small molecule interconversion
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0015949	biological_process	nucleobase-containing small molecule interconversion
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0015949	biological_process	nucleobase-containing small molecule interconversion
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process
G	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0015949	biological_process	nucleobase-containing small molecule interconversion
G	0016829	molecular_function	lyase activity
G	0016831	molecular_function	carboxy-lyase activity
G	0044205	biological_process	'de novo' UMP biosynthetic process
H	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0015949	biological_process	nucleobase-containing small molecule interconversion
H	0016829	molecular_function	lyase activity
H	0016831	molecular_function	carboxy-lyase activity
H	0044205	biological_process	'de novo' UMP biosynthetic process
I	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0015949	biological_process	nucleobase-containing small molecule interconversion
I	0016829	molecular_function	lyase activity
I	0016831	molecular_function	carboxy-lyase activity
I	0044205	biological_process	'de novo' UMP biosynthetic process
J	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
J	0006221	biological_process	pyrimidine nucleotide biosynthetic process
J	0015949	biological_process	nucleobase-containing small molecule interconversion
J	0016829	molecular_function	lyase activity
J	0016831	molecular_function	carboxy-lyase activity
J	0044205	biological_process	'de novo' UMP biosynthetic process
K	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0015949	biological_process	nucleobase-containing small molecule interconversion
K	0016829	molecular_function	lyase activity
K	0016831	molecular_function	carboxy-lyase activity
K	0044205	biological_process	'de novo' UMP biosynthetic process
L	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0015949	biological_process	nucleobase-containing small molecule interconversion
L	0016829	molecular_function	lyase activity
L	0016831	molecular_function	carboxy-lyase activity
L	0044205	biological_process	'de novo' UMP biosynthetic process
M	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
M	0006221	biological_process	pyrimidine nucleotide biosynthetic process
M	0015949	biological_process	nucleobase-containing small molecule interconversion
M	0016829	molecular_function	lyase activity
M	0016831	molecular_function	carboxy-lyase activity
M	0044205	biological_process	'de novo' UMP biosynthetic process
N	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
N	0006221	biological_process	pyrimidine nucleotide biosynthetic process
N	0015949	biological_process	nucleobase-containing small molecule interconversion
N	0016829	molecular_function	lyase activity
N	0016831	molecular_function	carboxy-lyase activity
N	0044205	biological_process	'de novo' UMP biosynthetic process
O	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
O	0006221	biological_process	pyrimidine nucleotide biosynthetic process
O	0015949	biological_process	nucleobase-containing small molecule interconversion
O	0016829	molecular_function	lyase activity
O	0016831	molecular_function	carboxy-lyase activity
O	0044205	biological_process	'de novo' UMP biosynthetic process
P	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
P	0006221	biological_process	pyrimidine nucleotide biosynthetic process
P	0015949	biological_process	nucleobase-containing small molecule interconversion
P	0016829	molecular_function	lyase activity
P	0016831	molecular_function	carboxy-lyase activity
P	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP A 301

Chain	Residue
A	ALA20
A	GLN201
A	GLY221
A	ARG222
B	ASP76
B	ILE77
B	THR80
A	ASP22
A	LYS44
A	ASP71
A	LYS73
A	LEU130
A	THR131
A	PRO189
A	ARG192

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP B 302

Chain	Residue
A	ASP76
A	ILE77
A	THR80
B	ALA20
B	ASP22
B	LYS44
B	ASP71
B	LYS73
B	LEU130
B	THR131
B	PRO189
B	ARG192
B	GLN201
B	GLY221
B	ARG222

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP C 303

Chain	Residue
C	ALA20
C	ASP22
C	LYS44
C	ASP71
C	LYS73
C	LEU130
C	THR131
C	PRO189
C	ARG192
C	GLN201
C	GLY221
C	ARG222
D	ASP76
D	ILE77
D	THR80

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP D 304

Chain	Residue
C	ASP76
C	ILE77
C	THR80
D	ALA20
D	ASP22
D	LYS44
D	ASP71
D	LYS73
D	LEU130
D	THR131
D	PRO189
D	ARG192
D	GLN201
D	GLY221
D	ARG222

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP E 305

Chain	Residue
E	ALA20
E	ASP22
E	LYS44
E	ASP71
E	LYS73
E	LEU130
E	THR131
E	PRO189
E	ARG192
E	GLN201
E	GLY221
E	ARG222
F	ASP76
F	ILE77
F	THR80

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP F 306

Chain	Residue
E	ASP76
E	ILE77
E	THR80
F	ALA20
F	ASP22
F	LYS44
F	ASP71
F	LYS73
F	LEU130
F	THR131
F	PRO189
F	ARG192
F	GLN201
F	GLY221
F	ARG222

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP G 307

Chain	Residue
G	GLN201
G	GLY221
G	ARG222
H	ASP76
H	ILE77
H	THR80
G	ALA20
G	ASP22
G	LYS44
G	ASP71
G	LYS73
G	LEU130
G	THR131
G	PRO189
G	ARG192

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP H 308

Chain	Residue
G	ASP76
G	ILE77
G	THR80
H	ALA20
H	ASP22
H	LYS44
H	ASP71
H	LYS73
H	LEU130
H	THR131
H	PRO189
H	ARG192
H	GLN201
H	GLY221
H	ARG222

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP I 309

Chain	Residue
I	ALA20
I	ASP22
I	LYS44
I	ASP71
I	LYS73
I	LEU130
I	THR131
I	PRO189
I	ARG192
I	GLN201
I	GLY221
I	ARG222
J	ASP76
J	ILE77
J	THR80

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP J 310

Chain	Residue
I	ASP76
I	ILE77
I	THR80
J	ALA20
J	ASP22
J	LYS44
J	ASP71
J	LYS73
J	LEU130
J	THR131
J	PRO189
J	ARG192
J	GLN201
J	GLY221
J	ARG222

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP K 311

Chain	Residue
K	ALA20
K	ASP22
K	LYS44
K	ASP71
K	LYS73
K	LEU130
K	THR131
K	PRO189
K	ARG192
K	GLN201
K	GLY221
K	ARG222
L	ASP76
L	ILE77
L	THR80

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP L 312

Chain	Residue
K	ASP76
K	ILE77
K	THR80
L	ALA20
L	ASP22
L	LYS44
L	ASP71
L	LYS73
L	LEU130
L	THR131
L	PRO189
L	ARG192
L	GLN201
L	GLY221
L	ARG222

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP M 313

Chain	Residue
M	ALA20
M	ASP22
M	LYS44
M	ASP71
M	LYS73
M	LEU130
M	THR131
M	PRO189
M	ARG192
M	GLN201
M	GLY221
M	ARG222
N	ASP76
N	ILE77
N	THR80

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP N 314

Chain	Residue
M	ASP76
M	ILE77
M	THR80
N	ALA20
N	ASP22
N	LYS44
N	ASP71
N	LYS73
N	LEU130
N	THR131
N	PRO189
N	ARG192
N	GLN201
N	GLY221
N	ARG222

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP O 315

Chain	Residue
O	ALA20
O	ASP22
O	LYS44
O	ASP71
O	LYS73
O	LEU130
O	THR131
O	PRO189
O	ARG192
O	GLN201
O	GLY221
O	ARG222
P	ASP76
P	ILE77
P	THR80

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BMP P 316

Chain	Residue
O	ASP76
O	ILE77
O	THR80
P	ALA20
P	ASP22
P	LYS44
P	ASP71
P	LYS73
P	LEU130
P	THR131
P	PRO189
P	ARG192
P	GLN201
P	GLY221
P	ARG222

Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFlDlKfhDIPnTA

Chain	Residue	Details
A	ILE68-ALA81

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	LYS73
J	LYS73
K	LYS73
L	LYS73
M	LYS73
N	LYS73
O	LYS73
P	LYS73
B	LYS73
C	LYS73
D	LYS73
E	LYS73
F	LYS73
G	LYS73
H	LYS73
I	LYS73

site_id	SWS_FT_FI2
Number of Residues	128
Details	BINDING:

Chain	Residue	Details
A	ASP22
B	LYS44
M	THR131
M	ARG192
M	GLN201
M	GLY221
M	ARG222
N	ASP22
N	LYS44
N	ASP71
N	THR131
N	ARG192
B	ASP71
N	GLN201
N	GLY221
N	ARG222
O	ASP22
O	LYS44
O	ASP71
O	THR131
O	ARG192
O	GLN201
O	GLY221
B	THR131
O	ARG222
P	ASP22
P	LYS44
P	ASP71
P	THR131
P	ARG192
P	GLN201
P	GLY221
P	ARG222
B	ARG192
B	GLN201
B	GLY221
B	ARG222
C	ASP22
C	LYS44
C	ASP71
A	LYS44
C	THR131
C	ARG192
C	GLN201
C	GLY221
C	ARG222
D	ASP22
D	LYS44
D	ASP71
D	THR131
D	ARG192
A	ASP71
D	GLN201
D	GLY221
D	ARG222
E	ASP22
E	LYS44
E	ASP71
E	THR131
E	ARG192
E	GLN201
E	GLY221
A	THR131
E	ARG222
F	ASP22
F	LYS44
F	ASP71
F	THR131
F	ARG192
F	GLN201
F	GLY221
F	ARG222
G	ASP22
A	ARG192
G	LYS44
G	ASP71
G	THR131
G	ARG192
G	GLN201
G	GLY221
G	ARG222
H	ASP22
H	LYS44
H	ASP71
A	GLN201
H	THR131
H	ARG192
H	GLN201
H	GLY221
H	ARG222
I	ASP22
I	LYS44
I	ASP71
I	THR131
I	ARG192
A	GLY221
I	GLN201
I	GLY221
I	ARG222
J	ASP22
J	LYS44
J	ASP71
J	THR131
J	ARG192
J	GLN201
J	GLY221
A	ARG222
J	ARG222
K	ASP22
K	LYS44
K	ASP71
K	THR131
K	ARG192
K	GLN201
K	GLY221
K	ARG222
L	ASP22
B	ASP22
L	LYS44
L	ASP71
L	THR131
L	ARG192
L	GLN201
L	GLY221
L	ARG222
M	ASP22
M	LYS44
M	ASP71

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)