Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0004866 | molecular_function | endopeptidase inhibitor activity |
| I | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| I | 0010951 | biological_process | negative regulation of endopeptidase activity |
| P | 0001869 | biological_process | negative regulation of complement activation, lectin pathway |
| P | 0004222 | molecular_function | metalloendopeptidase activity |
| P | 0005509 | molecular_function | calcium ion binding |
| P | 0005576 | cellular_component | extracellular region |
| P | 0005615 | cellular_component | extracellular space |
| P | 0006508 | biological_process | proteolysis |
| P | 0008233 | molecular_function | peptidase activity |
| P | 0008237 | molecular_function | metallopeptidase activity |
| P | 0008270 | molecular_function | zinc ion binding |
| P | 0010765 | biological_process | positive regulation of sodium ion transport |
| P | 0045959 | biological_process | negative regulation of complement activation, classical pathway |
| P | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN P 481 |
| Chain | Residue |
| I | SER1 |
| P | HIS176 |
| P | HIS180 |
| P | HIS186 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 482 |
| Chain | Residue |
| P | ASP290 |
| P | ARG253 |
| P | GLY255 |
| P | THR257 |
| P | ASP285 |
| P | GLY287 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 483 |
| Chain | Residue |
| P | GLY288 |
| P | ASP290 |
| P | THR327 |
| P | GLU329 |
| P | HOH491 |
| P | HOH520 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 484 |
| Chain | Residue |
| P | GLY334 |
| P | GLY336 |
| P | ASP338 |
| P | GLY351 |
| P | ALA353 |
| P | ASP356 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 485 |
| Chain | Residue |
| P | GLY352 |
| P | GLY354 |
| P | ASP356 |
| P | GLY369 |
| P | ALA371 |
| P | ASP374 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 486 |
| Chain | Residue |
| P | GLY370 |
| P | GLY372 |
| P | ASP374 |
| P | ASP400 |
| P | HOH492 |
| P | HOH533 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 487 |
| Chain | Residue |
| P | ASN343 |
| P | VAL345 |
| P | ASN347 |
| P | GLY360 |
| P | LEU362 |
| P | ASP365 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA P 488 |
| Chain | Residue |
| P | GLY361 |
| P | GLY363 |
| P | ASP365 |
| P | GLU383 |
| P | ASP390 |
| P | HOH495 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA P 489 |
| Chain | Residue |
| P | ASP446 |
| P | SER448 |
| P | ASP450 |
| P | HIS452 |
| P | ASP454 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLTHEIGHTL |
| Chain | Residue | Details |
| P | THR173-LEU182 | |
| site_id | PS00330 |
| Number of Residues | 19 |
| Details | HEMOLYSIN_CALCIUM Hemolysin-type calcium-binding region signature. DiLygglGaDqLwGGagaD |
| Chain | Residue | Details |
| P | ASP356-ASP374 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| P | GLU177 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | BINDING: |
| Chain | Residue | Details |
| P | HIS176 | |
| P | ASP290 | |
| P | THR327 | |
| P | GLU329 | |
| P | GLY334 | |
| P | GLY336 | |
| P | ASP338 | |
| P | ASN343 | |
| P | VAL345 | |
| P | ASN347 | |
| P | GLY351 | |
| P | HIS180 | |
| P | GLY352 | |
| P | ALA353 | |
| P | GLY354 | |
| P | ASP356 | |
| P | GLY360 | |
| P | GLY361 | |
| P | LEU362 | |
| P | GLY363 | |
| P | ASP365 | |
| P | GLY369 | |
| P | HIS186 | |
| P | GLY370 | |
| P | ALA371 | |
| P | GLY372 | |
| P | ASP374 | |
| P | GLU383 | |
| P | ASP390 | |
| P | ASP400 | |
| P | ASP446 | |
| P | SER448 | |
| P | ASP450 | |
| P | ARG253 | |
| P | HIS452 | |
| P | ASP454 | |
| P | GLY255 | |
| P | THR257 | |
| P | ASP285 | |
| P | GLY287 | |
| P | GLY288 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| P | GLU177 | |
| P | GLU194 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| P | GLU177 | |
