1JHW
Ca2+-binding Mimicry in the Crystal Structure of the Eu3+-Bound Mutant Human Macrophage Capping Protein Cap G
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001726 | cellular_component | ruffle |
| A | 0003779 | molecular_function | actin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005814 | cellular_component | centriole |
| A | 0007417 | biological_process | central nervous system development |
| A | 0008154 | biological_process | actin polymerization or depolymerization |
| A | 0008290 | cellular_component | F-actin capping protein complex |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030031 | biological_process | cell projection assembly |
| A | 0042470 | cellular_component | melanosome |
| A | 0042995 | cellular_component | cell projection |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0051014 | biological_process | actin filament severing |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0051016 | biological_process | barbed-end actin filament capping |
| A | 0051693 | biological_process | actin filament capping |
| A | 0065003 | biological_process | protein-containing complex assembly |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071803 | biological_process | positive regulation of podosome assembly |
| A | 0072686 | cellular_component | mitotic spindle |
| A | 0090543 | cellular_component | Flemming body |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EU3 A 401 |
| Chain | Residue |
| A | GLY45 |
| A | ASP46 |
| A | GLN320 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EU3 A 402 |
| Chain | Residue |
| A | SER254 |
| A | ASP279 |
| A | ASP280 |
| A | GLU304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"Gelsolin-like 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"Gelsolin-like 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Gelsolin-like 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
