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1JHW

Ca2+-binding Mimicry in the Crystal Structure of the Eu3+-Bound Mutant Human Macrophage Capping Protein Cap G

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005814cellular_componentcentriole
A0007417biological_processcentral nervous system development
A0008154biological_processactin polymerization or depolymerization
A0008290cellular_componentF-actin capping protein complex
A0015629cellular_componentactin cytoskeleton
A0019904molecular_functionprotein domain specific binding
A0022617biological_processextracellular matrix disassembly
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0044877molecular_functionprotein-containing complex binding
A0045296molecular_functioncadherin binding
A0051014biological_processactin filament severing
A0051015molecular_functionactin filament binding
A0051016biological_processbarbed-end actin filament capping
A0051693biological_processactin filament capping
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0071803biological_processpositive regulation of podosome assembly
A0072686cellular_componentmitotic spindle
A0090543cellular_componentFlemming body
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EU3 A 401
ChainResidue
AGLY45
AASP46
AGLN320

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EU3 A 402
ChainResidue
ASER254
AASP279
AASP280
AGLU304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:25944712
ChainResidueDetails
AMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
APRO337

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PDB entries from 2024-07-24

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