1JHF
LEXA G85D MUTANT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006508 | biological_process | proteolysis |
| A | 0006974 | biological_process | DNA damage response |
| A | 0009432 | biological_process | SOS response |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006281 | biological_process | DNA repair |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006508 | biological_process | proteolysis |
| B | 0006974 | biological_process | DNA damage response |
| B | 0009432 | biological_process | SOS response |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | THR27 |
| A | ARG28 |
| A | SER63 |
| A | ARG64 |
| A | HOH420 |
| B | ARG140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For autocatalytic cleavage activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 1155106, 3108885, 11551506 |
| Chain | Residue | Details |
| A | MET118 | |
| A | GLU152 | |
| A | LYS156 | |
| A | SER119 | |
| A | SER119 | |
| A | ASP127 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 1155106, 3108885, 11551506 |
| Chain | Residue | Details |
| B | MET118 | |
| B | GLU152 | |
| B | LYS156 | |
| B | SER119 | |
| B | SER119 | |
| B | ASP127 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 724 |
| Chain | Residue | Details |
| A | MET118 | electrostatic stabiliser |
| A | SER119 | electrostatic stabiliser |
| A | GLU152 | electrostatic stabiliser |
| A | LYS156 | proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 724 |
| Chain | Residue | Details |
| B | MET118 | electrostatic stabiliser |
| B | SER119 | electrostatic stabiliser |
| B | GLU152 | electrostatic stabiliser |
| B | LYS156 | proton acceptor, proton donor |
