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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1JFW

HOMONUCLEAR AND HETERONUCLEAR 1H-13C NUCLEAR MAGNETIC RESONANCE ASSIGNMENT AND STRUCTURAL CHARACTERIZATION OF A HIV-1 TAT PROTEIN

Replaces:  1FKU
Functional Information from GO Data
ChainGOidnamespacecontents
A0001069molecular_functionregulatory region RNA binding
A0001070molecular_functionRNA-binding transcription regulator activity
A0003723molecular_functionRNA binding
A0004865molecular_functionprotein serine/threonine phosphatase inhibitor activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0006351biological_processDNA-templated transcription
A0019080biological_processviral gene expression
A0019904molecular_functionprotein domain specific binding
A0030332molecular_functioncyclin binding
A0030430cellular_componenthost cell cytoplasm
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
A0039525biological_processsymbiont-mediated perturbation of host chromatin organization
A0039606biological_processsymbiont-mediated suppression of host translation initiation
A0042025cellular_componenthost cell nucleus
A0042805molecular_functionactinin binding
A0044196cellular_componenthost cell nucleolus
A0046872molecular_functionmetal ion binding
A0050434biological_processpositive regulation of viral transcription
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0052031biological_processsymbiont-mediated perturbation of host defense response
A0052170biological_processsymbiont-mediated suppression of host innate immune response
A0060081biological_processmembrane hyperpolarization
A1900182biological_processpositive regulation of protein localization to nucleus
A1901856biological_processnegative regulation of cellular respiration
A1990970molecular_functiontrans-activation response element binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues47
DetailsRegion: {"description":"Transactivation","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues23
DetailsRegion: {"description":"Interaction with human CREBBP","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues58
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues15
DetailsRegion: {"description":"Cysteine-rich","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsRegion: {"description":"Core","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues37
DetailsRegion: {"description":"Interaction with the host capping enzyme RNGTT","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsMotif: {"description":"Nuclear localization signal, RNA-binding (TAR), and protein transduction","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9891055","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsMotif: {"description":"Cell attachment site","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues11
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsCompositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues15
DetailsCompositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsSite: {"description":"Essential for Tat translocation through the endosomal membrane","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; by host PCAF","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10545121","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; by host EP300 and GCN5L2","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10545121","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11080476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11384967","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; by host EP300 and GCN5L2","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11080476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11384967","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Asymmetric dimethylarginine; by host PRMT6","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12883554","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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