1JFK

MINIMUM ENERGY REPRESENTATIVE STRUCTURE OF A CALCIUM BOUND EF-HAND PROTEIN FROM ENTAMOEBA HISTOLYTICA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001891	cellular_component	phagocytic cup
A	0003779	molecular_function	actin binding
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0006909	biological_process	phagocytosis
A	0031143	cellular_component	pseudopodium
A	0032231	biological_process	regulation of actin filament bundle assembly
A	0042995	cellular_component	cell projection
A	0045859	biological_process	regulation of protein kinase activity
A	0046872	molecular_function	metal ion binding
A	0050766	biological_process	positive regulation of phagocytosis
A	0051015	molecular_function	actin filament binding
A	1905303	biological_process	positive regulation of macropinocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 147

Chain	Residue
A	ASP10
A	ASN12
A	ASP14
A	ALA16
A	GLU21

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 159

Chain	Residue
A	ILE53
A	GLU57
A	ASP46
A	ASP48
A	ASN50
A	GLU52

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 171

Chain	Residue
A	ASP87
A	ASP89
A	LYS91
A	GLU96

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 183

Chain	Residue
A	ASP117
A	ASN119
A	ASP121
A	TYR123
A	ILE124
A	GLU128

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DVNGDGAVSyeEV

Chain	Residue	Details
A	ASP10-VAL22
A	ASP46-PHE58
A	ASP85-VAL97
A	ASP117-PHE129

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:11724551, ECO:0000269|PubMed:17554780, ECO:0000269|PubMed:20550906, ECO:0000269|PubMed:23782698, ECO:0000305|PubMed:22906057, ECO:0007744|PDB:1JFK, ECO:0007744|PDB:2M7M, ECO:0007744|PDB:2NXQ, ECO:0007744|PDB:3LI6, ECO:0007744|PDB:3PX1, ECO:0007744|PDB:3QJK, ECO:0007744|PDB:3ULG

Chain	Residue	Details
A	ASP10
A	GLU57
A	ASN12
A	ASP14
A	ALA16
A	GLU21
A	ASP46
A	ASP48
A	ASN50
A	GLU52

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:23782698, ECO:0007744|PDB:2M7N

Chain	Residue	Details
A	ASP85
A	ASP87
A	ASP89

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:11724551, ECO:0000269|PubMed:23782698, ECO:0007744|PDB:1JFK, ECO:0007744|PDB:2M7N

Chain	Residue	Details
A	LYS91
A	GLU96
A	ASP117
A	ASN119
A	ASP121
A	TYR123
A	GLU128

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