1JFI
Crystal Structure of the NC2-TBP-DNA Ternary Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0016251 | molecular_function | RNA polymerase II general transcription initiation factor activity |
| B | 0017025 | molecular_function | TBP-class protein binding |
| B | 0017054 | cellular_component | negative cofactor 2 complex |
| B | 0017055 | biological_process | negative regulation of RNA polymerase II transcription preinitiation complex assembly |
| B | 0045995 | biological_process | regulation of embryonic development |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0051123 | biological_process | RNA polymerase II preinitiation complex assembly |
| B | 0051302 | biological_process | regulation of cell division |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0072686 | cellular_component | mitotic spindle |
| B | 0090043 | biological_process | regulation of tubulin deacetylation |
| B | 0090575 | cellular_component | RNA polymerase II transcription regulator complex |
| B | 0140223 | molecular_function | general transcription initiation factor activity |
| B | 0140672 | cellular_component | ATAC complex |
| C | 0003677 | molecular_function | DNA binding |
| C | 0006352 | biological_process | DNA-templated transcription initiation |
Functional Information from PROSITE/UniProt
| site_id | PS00351 |
| Number of Residues | 50 |
| Details | TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV |
| Chain | Residue | Details |
| C | TYR392-VAL441 | |
| C | TYR483-LEU532 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | Domain: {"description":"Histone-fold","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 77 |
| Details | Repeat: {"description":"2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
