1JF8
X-ray structure of reduced C10S, C15A arsenate reductase from pI258
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030612 | molecular_function | arsenate reductase (thioredoxin) activity |
| A | 0046685 | biological_process | response to arsenic-containing substance |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT A 132 |
| Chain | Residue |
| A | SER10 |
| A | SER14 |
| A | ALA15 |
| A | ARG16 |
| A | SER17 |
| A | TRS134 |
| A | HOH137 |
| A | HOH145 |
| A | HOH319 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 133 |
| Chain | Residue |
| A | ASN13 |
| A | SER36 |
| A | THR63 |
| A | ASP65 |
| A | HOH144 |
| A | HOH199 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TRS A 134 |
| Chain | Residue |
| A | SER14 |
| A | HIS42 |
| A | GLU54 |
| A | ASP105 |
| A | ALA107 |
| A | TRP111 |
| A | GLN115 |
| A | BCT132 |
| A | HOH137 |
| A | HOH310 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01624","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11573087","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"12072565","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11573087","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12072565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12682056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15159594","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16797027","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 14 |
| Details | M-CSA 143 |
| Chain | Residue | Details |
| A | SER10 | electrofuge, electrophile, nucleofuge, nucleophile |
| A | THR63 | |
| A | ASP65 | |
| A | CYS82 | electrofuge, electrophile, hydrogen bond acceptor, nucleofuge, nucleophile |
| A | CYS89 | hydrogen bond acceptor, nucleofuge, nucleophile |
| A | ASP105 | electrostatic stabiliser, hydrogen bond acceptor |
| A | THR11 | electrostatic stabiliser, hydrogen bond donor |
| A | GLY12 | electrostatic stabiliser, hydrogen bond donor |
| A | ASN13 | electrostatic stabiliser, hydrogen bond donor |
| A | SER14 | electrostatic stabiliser, hydrogen bond donor |
| A | ALA15 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG16 | electrostatic stabiliser, hydrogen bond donor |
| A | SER17 | electrostatic stabiliser, hydrogen bond donor |
| A | SER36 |
