1JEN
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| A | 0006597 | biological_process | spermine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| C | 0006597 | biological_process | spermine biosynthetic process |
| C | 0008295 | biological_process | spermidine biosynthetic process |
| D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| D | 0008295 | biological_process | spermidine biosynthetic process |
Functional Information from PDB Data
| site_id | PVL |
| Number of Residues | 2 |
| Details | THE PYRUVOYL COFACTOR IS CREATED DURING THE AUTOCATALYTIC PROENZYME CLEAVAGE REACTION, AND IS A REQUIRED FOR THE ENZYME-CATALYZED DECARBOXYLATION OF ADOMET. |
| Chain | Residue |
| A | PYR68 |
| C | PYR68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"1917972","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor; for catalytic activity","evidences":[{"source":"PubMed","id":"10029540","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; for processing activity","evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 10029540, 10378277, 19997761 |
| Chain | Residue | Details |
| A | CYS82 | |
| A | PYR68 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 575 |
| Chain | Residue | Details |
| B | SER19 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 575 |
| Chain | Residue | Details |
| D | SER19 | proton shuttle (general acid/base) |
