Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1JDB

CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0004359	molecular_function	glutaminase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
H	0000166	molecular_function	nucleotide binding
H	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016597	molecular_function	amino acid binding
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046872	molecular_function	metal ion binding
I	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I	0004359	molecular_function	glutaminase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005951	cellular_component	carbamoyl-phosphate synthase complex
I	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0006526	biological_process	arginine biosynthetic process
I	0006541	biological_process	glutamine metabolic process
I	0016874	molecular_function	ligase activity
I	0019856	biological_process	pyrimidine nucleobase biosynthetic process
I	0044205	biological_process	'de novo' UMP biosynthetic process
I	0046982	molecular_function	protein heterodimerization activity
K	0000166	molecular_function	nucleotide binding
K	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
K	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005951	cellular_component	carbamoyl-phosphate synthase complex
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0006526	biological_process	arginine biosynthetic process
K	0006541	biological_process	glutamine metabolic process
K	0008652	biological_process	amino acid biosynthetic process
K	0016597	molecular_function	amino acid binding
K	0016874	molecular_function	ligase activity
K	0019856	biological_process	pyrimidine nucleobase biosynthetic process
K	0044205	biological_process	'de novo' UMP biosynthetic process
K	0046872	molecular_function	metal ion binding
L	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L	0004359	molecular_function	glutaminase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005951	cellular_component	carbamoyl-phosphate synthase complex
L	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0006526	biological_process	arginine biosynthetic process
L	0006541	biological_process	glutamine metabolic process
L	0016874	molecular_function	ligase activity
L	0019856	biological_process	pyrimidine nucleobase biosynthetic process
L	0044205	biological_process	'de novo' UMP biosynthetic process
L	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 1073

Chain	Residue
B	MET173
B	GLU298
B	ASN300
B	MN1074
B	PO41078
B	ADP1093
B	HOH1097

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 1074

Chain	Residue
B	MN1073
B	K1077
B	PO41078
B	ADP1093
B	HOH1098
B	GLN284
B	GLU298

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 1075

Chain	Residue
B	GLU214
B	ASN235
B	ASP237
B	ALA238
B	ILE241
B	SER246

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K B 1076

Chain	Residue
B	ALA125
B	GLU126
B	GLU298
B	MET299
B	ASN300
B	HOH1097
B	HOH1100
B	HOH1105

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 1077

Chain	Residue
B	GLU216
B	THR243
B	ASN282
B	GLN284
B	MN1074
B	PO41078

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 B 1078

Chain	Residue
B	MET173
B	GLY174
B	HIS242
B	GLN284
B	GLU298
B	ASN300
B	ARG302
B	ARG305
B	MN1073
B	MN1074
B	K1077
B	ADP1093
B	HOH1099
B	HOH1106

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 1079

Chain	Residue
B	GLN828
B	GLU840
B	ADP1094
B	HOH1107
B	HOH1108

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 1080

Chain	Residue
B	GLU840
B	ASN842
B	ADP1094
B	HOH1109

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 1081

Chain	Residue
B	GLU760
B	HIS780
B	GLU782
B	GLN783
B	VAL786
B	SER791

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 1082

Chain	Residue
B	SER947
B	VAL948
B	LYS953
B	THR973
B	GLY975
B	THR976
B	LYS992
B	GLN1091

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 1083

Chain	Residue
B	THR142
B	ALA143
B	HOH1272
B	HOH1275

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 383

Chain	Residue
C	HIS16
C	ASP112
C	HOH433
C	HOH434
C	HOH435

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K B 1084

Chain	Residue
B	ASP83
B	GLY111
B	THR113

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1085

Chain	Residue
B	ASN288
B	ASN291
B	ARG293

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 1086

Chain	Residue
B	ALA369
B	ASN370
B	PHE899
B	PRO900
B	GLY901

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1087

Chain	Residue
B	GLN92
B	THR172
B	MET173
B	HOH1149

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 1088

Chain	Residue
B	TRP70

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 384

Chain	Residue
C	ASP114
C	HOH434

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1089

Chain	Residue
B	ASN484
B	LYS474

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1090

Chain	Residue
B	ARG844
B	ALA846
B	ARG847

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 1073

Chain	Residue
E	GLU298
E	ASN300
E	MN1074
E	PO41078
E	ADP1095
E	HOH1215

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 1074

Chain	Residue
E	GLN284
E	GLU298
E	MN1073
E	K1077
E	PO41078
E	ADP1095
E	HOH1216

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 1075

Chain	Residue
E	GLU214
E	ASN235
E	ASP237
E	ALA238
E	ILE241
E	SER246

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 1076

Chain	Residue
E	ALA125
E	GLU126
E	GLU298
E	MET299
E	ASN300
E	HOH1218
E	HOH1223

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 1077

Chain	Residue
E	GLU216
E	THR243
E	ASN282
E	GLN284
E	MN1074
E	PO41078
E	HOH1217

site_id	CC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 E 1078

Chain	Residue
E	MET173
E	GLY174
E	HIS242
E	GLN284
E	GLU298
E	ASN300
E	ARG302
E	ARG305
E	MN1073
E	MN1074
E	K1077
E	ADP1095
E	HOH1217
E	HOH1224

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 1079

Chain	Residue
E	GLN828
E	GLU840
E	ADP1096
E	HOH1225
E	HOH1226

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN E 1080

Chain	Residue
E	GLU840
E	ASN842
E	ADP1096
E	HOH1227

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 1081

Chain	Residue
E	GLU760
E	HIS780
E	GLU782
E	GLN783
E	VAL786
E	SER791

site_id	DC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 E 1082

Chain	Residue
E	SER947
E	LYS953
E	THR973
E	GLY975
E	THR976
E	LYS992
E	GLN1093
E	HOH1236

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 1083

Chain	Residue
E	THR142
E	ALA143
E	HOH1387
E	HOH1389
E	HOH1390

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K F 383

Chain	Residue
F	HIS16
F	ASP112
F	HOH1809

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 1084

Chain	Residue
E	ASP83
E	GLY111
E	THR113
E	HOH2318

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 1085

Chain	Residue
E	ALA671
E	GLU672
E	GLU840
E	VAL841
E	ASN842

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 1086

Chain	Residue
E	ASN288
E	ASN291
E	ARG293

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 1087

Chain	Residue
E	ALA369
E	ASN370
E	PHE899
E	PRO900
E	GLY901

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 1088

Chain	Residue
E	THR172
E	MET173
E	HOH1280
E	HOH1340

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 1089

Chain	Residue
E	TRP70

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 384

Chain	Residue
F	PHE15
F	ASP114

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 1090

Chain	Residue
E	LYS474
E	ASN484
E	HOH1708

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 1091

Chain	Residue
E	ALA119
E	HOH1347
E	HOH1352

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 1092

Chain	Residue
E	PHE577
E	ARG844
E	ALA846
E	ARG847

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 1073

Chain	Residue
H	GLU298
H	ASN300
H	MN1074
H	PO41078
H	ADP1092
H	HOH1107

site_id	EC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN H 1074

Chain	Residue
H	GLN284
H	GLU298
H	MN1073
H	K1077
H	PO41078
H	ADP1092
H	HOH1108

site_id	EC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K H 1075

Chain	Residue
H	GLU214
H	ASN235
H	ASP237
H	ALA238
H	ILE241
H	SER246

site_id	FC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K H 1076

Chain	Residue
H	ALA125
H	GLU126
H	GLU298
H	MET299
H	ASN300
H	HOH1107
H	HOH1110
H	HOH1115

site_id	FC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K H 1077

Chain	Residue
H	GLU216
H	THR243
H	ASN282
H	GLN284
H	MN1074
H	PO41078
H	HOH1109

site_id	FC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 H 1078

Chain	Residue
H	MET173
H	GLY174
H	HIS242
H	GLN284
H	GLU298
H	ASN300
H	ARG302
H	ARG305
H	MN1073
H	MN1074
H	K1077
H	ADP1092
H	HOH1109
H	HOH1116

site_id	FC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 1079

Chain	Residue
H	GLN828
H	GLU840
H	MN1080
H	ADP1093
H	HOH1117
H	HOH1118

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 1080

Chain	Residue
H	GLU840
H	ASN842
H	MN1079
H	ADP1093
H	HOH1119

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K H 1081

Chain	Residue
H	GLU760
H	HIS780
H	GLU782
H	GLN783
H	VAL786
H	SER791

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 H 1082

Chain	Residue
H	LYS953
H	THR973
H	GLY975
H	THR976
H	LYS992
H	GLN1090

site_id	FC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K H 1083

Chain	Residue
H	THR142
H	ALA143
H	HOH1280
H	HOH1282

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K I 383

Chain	Residue
H	HOH1654
I	HIS16
I	ASP112
I	HOH3054

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 1084

Chain	Residue
H	ASN288
H	ASN291
H	ARG293

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL H 1085

Chain	Residue
H	ALA369
H	ASN370
H	PHE899
H	PRO900
H	GLY901

site_id	GC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 1086

Chain	Residue
H	THR172
H	MET173
H	HOH1170

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL H 1087

Chain	Residue
H	TRP70

site_id	GC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL I 384

Chain	Residue
I	PHE15
I	ILE113
I	ASP114

site_id	GC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 1088

Chain	Residue
H	LYS474
H	ASN484

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 1089

Chain	Residue
H	PHE577
H	ARG844
H	ALA846
H	ARG847

site_id	GC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN K 1073

Chain	Residue
K	GLU298
K	ASN300
K	MN1074
K	PO41078
K	ADP1095
K	HOH1111

site_id	GC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN K 1074

Chain	Residue
K	GLN284
K	GLU298
K	MN1073
K	K1077
K	PO41078
K	ADP1095
K	HOH1112

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K K 1075

Chain	Residue
K	GLU214
K	ASN235
K	ASP237
K	ALA238
K	ILE241
K	SER246

site_id	HC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K K 1076

Chain	Residue
K	ALA125
K	GLU126
K	GLU298
K	MET299
K	ASN300
K	HOH1111
K	HOH1114
K	HOH1119

site_id	HC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K K 1077

Chain	Residue
K	GLU216
K	THR243
K	ASN282
K	GLN284
K	MN1074
K	PO41078
K	HOH1113

site_id	HC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 K 1078

Chain	Residue
K	MET173
K	GLY174
K	HIS242
K	GLN284
K	GLU298
K	ASN300
K	ARG302
K	ARG305
K	MN1073
K	MN1074
K	K1077
K	ADP1095
K	HOH1113
K	HOH1120

site_id	HC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN K 1079

Chain	Residue
K	GLN828
K	GLU840
K	MN1080
K	ADP1096
K	HOH1121
K	HOH1122

site_id	HC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN K 1080

Chain	Residue
K	GLU840
K	ASN842
K	MN1079
K	ADP1096
K	HOH1123

site_id	HC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K K 1081

Chain	Residue
K	GLU760
K	HIS780
K	GLU782
K	GLN783
K	VAL786
K	SER791

site_id	HC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 K 1082

Chain	Residue
K	LYS953
K	THR973
K	GLY975
K	THR976
K	LYS992
K	GLN1093
K	HOH1130

site_id	HC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K K 1083

Chain	Residue
K	THR142
K	ALA143
K	HOH1289
K	HOH1290

site_id	IC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K L 383

Chain	Residue
L	HIS16
L	ASP112
L	HOH4230

site_id	IC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K K 1084

Chain	Residue
K	GLU672
K	GLU840
K	VAL841
K	ASN842

site_id	IC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K K 1085

Chain	Residue
K	CYS550
K	ASN553
K	HOH1589

site_id	IC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL K 1086

Chain	Residue
K	ASN288
K	ASN291
K	ARG293

site_id	IC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL K 1087

Chain	Residue
K	ALA369
K	ASN370
K	PHE899
K	PRO900
K	GLY901

site_id	IC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL K 1088

Chain	Residue
K	THR172
K	MET173
K	NET1098
K	HOH1175

site_id	IC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL K 1089

Chain	Residue
K	TRP70

site_id	IC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL L 384

Chain	Residue
L	PHE15
L	ASP114

site_id	IC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL K 1090

Chain	Residue
K	LYS474
K	ASN484
K	HOH1568

site_id	JC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL K 1091

Chain	Residue
K	ARG844
K	ARG847

site_id	JC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 K 1092

Chain	Residue
K	GLU559
K	TYR593

site_id	JC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GLN B 1091

Chain	Residue
B	ASN1014
B	THR1015
B	THR1016
B	ASP1024
B	SER1025
B	PO41082

site_id	JC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLN B 1092

Chain	Residue
B	ARG527
B	ALA536
B	THR537
B	GLU551
B	ASN553
B	HOH1117
B	HOH1118
B	HOH1120
C	ARG120
C	ARG123

site_id	JC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GLN E 1093

Chain	Residue
E	VAL948
E	ASN1014
E	THR1015
E	THR1016
E	ASP1024
E	SER1025
E	ILE1028
E	PO41082

site_id	JC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GLN E 1094

Chain	Residue
E	ARG527
E	ALA536
E	THR537
E	GLU551
E	ASN553
E	HOH1239
E	HOH1240
F	ARG120
F	ARG123

site_id	JC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GLN H 1090

Chain	Residue
H	VAL948
H	ASN1014
H	THR1015
H	THR1016
H	ASP1024
H	SER1025
H	PO41082

site_id	JC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GLN H 1091

Chain	Residue
H	ARG527
H	ALA536
H	THR537
H	GLU551
H	ASN553
H	HOH1128
H	HOH1129
I	ARG120
I	ARG123

site_id	JC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GLN K 1093

Chain	Residue
K	VAL948
K	ASN1014
K	THR1015
K	THR1016
K	ASP1024
K	SER1025
K	PO41082

site_id	KC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLN K 1094

Chain	Residue
K	ARG527
K	ALA536
K	THR537
K	GLU551
K	ASN553
K	HOH1131
K	HOH1132
K	HOH1134
L	ARG120
L	ARG123

site_id	KC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP B 1093

Chain	Residue
B	ARG128
B	ILE166
B	ARG168
B	THR172
B	MET173
B	GLY174
B	GLY175
B	GLU207
B	SER208
B	LEU209
B	ILE210
B	GLU214
B	MET239
B	GLY240
B	ILE241
B	HIS242
B	THR243
B	GLN284
B	ILE297
B	GLU298
B	THR375
B	MN1073
B	MN1074
B	PO41078
B	HOH1098
B	HOH1102
B	HOH1103
B	HOH1104

site_id	KC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP B 1094

Chain	Residue
B	PRO689
B	ARG714
B	MET724
B	HIS753
B	PHE754
B	LEU755
B	GLU760
B	ALA784
B	GLY785
B	VAL786
B	HIS787
B	SER788
B	GLN828
B	GLU840
B	MN1079
B	MN1080
B	HOH1107
B	HOH1108
B	HOH1109
B	HOH1110

site_id	KC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN B 1095

Chain	Residue
B	GLU782
B	ASP790
B	GLU891
B	VAL892
B	LEU906
B	TYR1039
B	ASP1040
B	THR1041
B	HOH1112
B	HOH1114

site_id	KC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NET B 1096

Chain	Residue
B	THR93
B	ASN935

site_id	KC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP E 1095

Chain	Residue
E	ARG128
E	ILE166
E	ARG168
E	THR172
E	MET173
E	GLY174
E	GLY175
E	GLU207
E	LEU209
E	ILE210
E	GLU214
E	MET239
E	GLY240
E	ILE241
E	HIS242
E	THR243
E	GLN284
E	ILE297
E	GLU298
E	THR375
E	MN1073
E	MN1074
E	PO41078
E	HOH1215
E	HOH1216
E	HOH1220
E	HOH1222

site_id	KC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP E 1096

Chain	Residue
E	PRO689
E	ARG714
E	MET724
E	HIS753
E	PHE754
E	LEU755
E	GLU760
E	GLY785
E	VAL786
E	HIS787
E	SER788
E	GLN828
E	GLU840
E	MN1079
E	MN1080
E	HOH1225
E	HOH1226
E	HOH1228
E	HOH1229
E	HOH1230

site_id	KC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN E 1097

Chain	Residue
E	GLU782
E	ASP790
E	ALA792
E	GLU891
E	LEU906
E	TYR1039
E	ASP1040
E	THR1041
E	HOH1232
E	HOH1233
E	HOH1234

site_id	KC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET E 1098

Chain	Residue
E	THR93
E	ASN96
E	ASN935

site_id	LC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP H 1092

Chain	Residue
H	ARG128
H	ILE166
H	ARG168
H	THR172
H	MET173
H	GLY174
H	GLY175
H	GLU207
H	LEU209
H	ILE210
H	GLU214
H	MET239
H	GLY240
H	ILE241
H	HIS242
H	THR243
H	GLN284
H	ILE297
H	GLU298
H	THR375
H	MN1073
H	MN1074
H	PO41078
H	HOH1107
H	HOH1108
H	HOH1112
H	HOH1113
H	HOH1114

site_id	LC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP H 1093

Chain	Residue
H	PRO689
H	ARG714
H	MET724
H	HIS753
H	PHE754
H	LEU755
H	GLU760
H	ALA784
H	GLY785
H	VAL786
H	HIS787
H	SER788
H	GLN828
H	GLU840
H	MN1079
H	MN1080
H	HOH1117
H	HOH1118
H	HOH1120
H	HOH1121
H	HOH1122

site_id	LC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN H 1094

Chain	Residue
H	GLU782
H	ASP790
H	GLU891
H	VAL892
H	LEU906
H	TYR1039
H	ASP1040
H	THR1041
H	HOH1124
H	HOH1126

site_id	LC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET H 1095

Chain	Residue
H	GLN21
H	THR93
H	ASN96

site_id	LC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP K 1095

Chain	Residue
K	ARG128
K	ILE166
K	ARG168
K	THR172
K	MET173
K	GLY174
K	GLY175
K	GLU207
K	LEU209
K	ILE210
K	GLU214
K	MET239
K	GLY240
K	ILE241
K	HIS242
K	THR243
K	GLN284
K	ILE297
K	GLU298
K	THR375
K	MN1073
K	MN1074
K	PO41078
K	HOH1111
K	HOH1112
K	HOH1116
K	HOH1118

site_id	LC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP K 1096

Chain	Residue
K	PRO689
K	ARG714
K	HIS753
K	PHE754
K	LEU755
K	GLU760
K	ALA784
K	GLY785
K	VAL786
K	HIS787
K	SER788
K	GLN828
K	GLU840
K	PRO908
K	MN1079
K	MN1080
K	HOH1122
K	HOH1123

site_id	LC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ORN K 1097

Chain	Residue
K	GLU782
K	ASP790
K	GLU891
K	LEU906
K	TYR1039
K	ASP1040
K	THR1041
K	HOH1126
K	HOH1128

site_id	LC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET K 1098

Chain	Residue
K	GLN21
K	THR93
K	CL1088

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
B	PHE163-GLY177
B	TYR709-ALA723

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
B	VAL296-VAL303
B	LEU838-ALA845

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_01209

Chain	Residue	Details
C	CYS269
B	THR243
B	PRO715
B	PHE754
B	ASP756
B	VAL761
B	VAL786
B	HIS787
B	SER788
B	GLY789
E	ARG129
F	CYS269
E	PRO169
E	GLY175
E	SER176
E	SER208
E	ILE210
E	TYR215
E	ILE241
E	HIS242
E	THR243
E	PRO715
I	CYS269
E	PHE754
E	ASP756
E	VAL761
E	VAL786
E	HIS787
E	SER788
E	GLY789
H	ARG129
H	PRO169
H	GLY175
L	CYS269
H	SER176
H	SER208
H	ILE210
H	TYR215
H	ILE241
H	HIS242
H	THR243
H	PRO715
H	PHE754
H	ASP756
B	SER208
H	VAL761
H	VAL786
H	HIS787
H	SER788
H	GLY789
K	ARG129
K	PRO169
K	GLY175
K	SER176
K	SER208
B	ILE210
K	ILE210
K	TYR215
K	ILE241
K	HIS242
K	THR243
K	PRO715
K	PHE754
K	ASP756
K	VAL761
K	VAL786
B	TYR215
K	HIS787
K	SER788
K	GLY789
B	ILE241
B	HIS242

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_01209

Chain	Residue	Details
C	HIS353
C	GLU355
F	HIS353
F	GLU355
I	HIS353
I	GLU355
L	HIS353
L	GLU355

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01209, ECO:0000269\|PubMed:10587438, ECO:0007744\|PDB:1C3O

Chain	Residue	Details
C	SER47
F	GLY241
F	GLY243
F	LEU270
F	GLN273
F	ASN311
F	GLY313
F	PHE314
I	SER47
I	GLY241
I	GLY243
C	GLY241
I	LEU270
I	GLN273
I	ASN311
I	GLY313
I	PHE314
L	SER47
L	GLY241
L	GLY243
L	LEU270
L	GLN273
C	GLY243
L	ASN311
L	GLY313
L	PHE314
C	LEU270
C	GLN273
C	ASN311
C	GLY313
C	PHE314
F	SER47

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01210, ECO:0000269\|PubMed:10428826, ECO:0000269\|PubMed:9636022, ECO:0007744\|PDB:1CE8

Chain	Residue	Details
B	PHE829
E	PHE829
H	PHE829
K	PHE829

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01210, ECO:0000269\|PubMed:10029528, ECO:0000269\|PubMed:10089390, ECO:0000269\|PubMed:10428826, ECO:0000269\|PubMed:9636022, ECO:0007744\|PDB:1CE8

Chain	Residue	Details
B	VAL841
E	VAL841
H	VAL841
K	VAL841

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01210, ECO:0000269\|PubMed:10029528, ECO:0000269\|PubMed:10089390

Chain	Residue	Details
B	PRO843
E	PRO843
H	PRO843
K	PRO843

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269
F	GLU355

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
I	HIS353
I	CYS269
I	GLU355

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
C	HIS353
C	CYS269
C	GLU355

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
L	HIS353
L	CYS269
L	GLU355

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
C	HIS353
C	CYS269

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
I	HIS353
I	CYS269

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
L	HIS353
L	CYS269

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
C	CYS269	covalent catalysis, proton shuttle (general acid/base)
B	VAL303	electrostatic stabiliser
B	PRO715	electrostatic stabiliser
B	GLY721	electrostatic stabiliser
B	ARG722	electrostatic stabiliser
B	VAL761	steric role
B	PHE829	metal ligand
B	VAL841	metal ligand
B	PRO843	metal ligand
B	THR848	electrostatic stabiliser
C	HIS353	proton shuttle (general acid/base)
C	GLU355	steric role
B	TYR215	steric role
B	THR243	proton shuttle (general acid/base)
B	VAL283	electrostatic stabiliser
B	PHE285	metal ligand
B	MET299	metal ligand
B	PRO301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	CYS269	covalent catalysis, proton shuttle (general acid/base)
E	VAL303	electrostatic stabiliser
E	PRO715	electrostatic stabiliser
E	GLY721	electrostatic stabiliser
E	ARG722	electrostatic stabiliser
E	VAL761	steric role
E	PHE829	metal ligand
E	VAL841	metal ligand
E	PRO843	metal ligand
E	THR848	electrostatic stabiliser
F	HIS353	proton shuttle (general acid/base)
F	GLU355	steric role
E	TYR215	steric role
E	THR243	proton shuttle (general acid/base)
E	VAL283	electrostatic stabiliser
E	PHE285	metal ligand
E	MET299	metal ligand
E	PRO301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
I	CYS269	covalent catalysis, proton shuttle (general acid/base)
H	VAL303	electrostatic stabiliser
H	PRO715	electrostatic stabiliser
H	GLY721	electrostatic stabiliser
H	ARG722	electrostatic stabiliser
H	VAL761	steric role
H	PHE829	metal ligand
H	VAL841	metal ligand
H	PRO843	metal ligand
H	THR848	electrostatic stabiliser
I	HIS353	proton shuttle (general acid/base)
I	GLU355	steric role
H	TYR215	steric role
H	THR243	proton shuttle (general acid/base)
H	VAL283	electrostatic stabiliser
H	PHE285	metal ligand
H	MET299	metal ligand
H	PRO301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
L	CYS269	covalent catalysis, proton shuttle (general acid/base)
K	VAL303	electrostatic stabiliser
K	PRO715	electrostatic stabiliser
K	GLY721	electrostatic stabiliser
K	ARG722	electrostatic stabiliser
K	VAL761	steric role
K	PHE829	metal ligand
K	VAL841	metal ligand
K	PRO843	metal ligand
K	THR848	electrostatic stabiliser
L	HIS353	proton shuttle (general acid/base)
L	GLU355	steric role
K	TYR215	steric role
K	THR243	proton shuttle (general acid/base)
K	VAL283	electrostatic stabiliser
K	PHE285	metal ligand
K	MET299	metal ligand
K	PRO301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)