1JC5
Crystal Structure of Native Methylmalonyl-CoA Epimerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004493 | molecular_function | methylmalonyl-CoA epimerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0046491 | biological_process | L-methylmalonyl-CoA metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004493 | molecular_function | methylmalonyl-CoA epimerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0046491 | biological_process | L-methylmalonyl-CoA metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004493 | molecular_function | methylmalonyl-CoA epimerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0046491 | biological_process | L-methylmalonyl-CoA metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004493 | molecular_function | methylmalonyl-CoA epimerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0046491 | biological_process | L-methylmalonyl-CoA metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004493 | molecular_function | methylmalonyl-CoA epimerase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0046491 | biological_process | L-methylmalonyl-CoA metabolic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004493 | molecular_function | methylmalonyl-CoA epimerase activity |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0046491 | biological_process | L-methylmalonyl-CoA metabolic process |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | THR58 |
| A | GLU59 |
| A | HIS60 |
| A | MET61 |
| B | THR58 |
| B | HIS60 |
| B | MET61 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | GLN65 |
| A | GLY121 |
| A | THR122 |
| A | GLU141 |
| A | HOH203 |
| A | HIS12 |
| A | GLU48 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 203 |
| Chain | Residue |
| B | HIS12 |
| B | GLU48 |
| B | GLN65 |
| B | GLY121 |
| B | THR122 |
| B | ILE127 |
| B | GLU141 |
| B | HOH223 |
| B | HOH235 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 204 |
| Chain | Residue |
| C | THR58 |
| C | GLU59 |
| C | HIS60 |
| C | MET61 |
| D | THR58 |
| D | HIS60 |
| D | MET61 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 205 |
| Chain | Residue |
| C | HIS12 |
| C | GLN65 |
| C | GLY121 |
| C | THR122 |
| C | ILE127 |
| C | GLU141 |
| C | HOH206 |
| C | HOH237 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 206 |
| Chain | Residue |
| D | HIS12 |
| D | GLU48 |
| D | GLN65 |
| D | THR122 |
| D | ASN125 |
| D | ILE127 |
| D | GLU141 |
| D | HOH209 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 E 207 |
| Chain | Residue |
| E | THR58 |
| E | GLU59 |
| E | HIS60 |
| E | MET61 |
| F | THR58 |
| F | GLU59 |
| F | HIS60 |
| F | MET61 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 E 208 |
| Chain | Residue |
| E | HIS12 |
| E | GLU48 |
| E | GLN65 |
| E | GLY121 |
| E | THR122 |
| E | ASN125 |
| E | ILE127 |
| E | GLU141 |
| E | HOH210 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 F 209 |
| Chain | Residue |
| F | HIS12 |
| F | GLN65 |
| F | THR122 |
| F | ILE127 |
| F | GLU141 |
| F | HOH218 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 210 |
| Chain | Residue |
| B | TYR115 |
| B | ASP116 |
| B | GLU117 |
| C | LYS133 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fro |
| Chain | Residue | Details |
| A | GLU141 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fro |
| Chain | Residue | Details |
| B | GLU141 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fro |
| Chain | Residue | Details |
| C | GLU141 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fro |
| Chain | Residue | Details |
| D | GLU141 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fro |
| Chain | Residue | Details |
| E | GLU141 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fro |
| Chain | Residue | Details |
| F | GLU141 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 33 |
| Chain | Residue | Details |
| A | HIS12 | metal ligand |
| A | GLU48 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLN65 | metal ligand |
| A | HIS91 | metal ligand |
| A | GLU141 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 33 |
| Chain | Residue | Details |
| B | HIS12 | metal ligand |
| B | GLU48 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | GLN65 | metal ligand |
| B | HIS91 | metal ligand |
| B | GLU141 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 33 |
| Chain | Residue | Details |
| C | HIS12 | metal ligand |
| C | GLU48 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | GLN65 | metal ligand |
| C | HIS91 | metal ligand |
| C | GLU141 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 33 |
| Chain | Residue | Details |
| D | HIS12 | metal ligand |
| D | GLU48 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | GLN65 | metal ligand |
| D | HIS91 | metal ligand |
| D | GLU141 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 33 |
| Chain | Residue | Details |
| E | HIS12 | metal ligand |
| E | GLU48 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | GLN65 | metal ligand |
| E | HIS91 | metal ligand |
| E | GLU141 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 33 |
| Chain | Residue | Details |
| F | HIS12 | metal ligand |
| F | GLU48 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | GLN65 | metal ligand |
| F | HIS91 | metal ligand |
| F | GLU141 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
