1J99

CRYSTAL STRUCTURE OF HUMAN DEHYDROEPIANDROSTERONE SULFOTRANSFERASE IN COMPLEX WITH SUBSTRATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004027	molecular_function	alcohol sulfotransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006068	biological_process	ethanol catabolic process
A	0006629	biological_process	lipid metabolic process
A	0006790	biological_process	sulfur compound metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008146	molecular_function	sulfotransferase activity
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008206	biological_process	bile acid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016740	molecular_function	transferase activity
A	0030573	biological_process	bile acid catabolic process
A	0042403	biological_process	thyroid hormone metabolic process
A	0047704	molecular_function	bile-salt sulfotransferase activity
A	0050294	molecular_function	steroid sulfotransferase activity
A	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
A	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
A	0051923	biological_process	sulfation
A	0160025	biological_process	sensory perception of itch

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HGI A 301

Chain	Residue
A	CYS55

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HGI A 302

Chain	Residue
A	PHE150
A	CYS154
A	ASP265

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HGI A 303

Chain	Residue
A	CYS199
A	GLN200
A	LYS204
A	THR205
A	LEU206

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site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AND A 401

Chain	Residue
A	PRO14
A	MET16
A	PRO43
A	LYS44
A	TRP72
A	TRP77
A	HIS99
A	PHE133
A	MET137
A	LYS138
A	TYR231
A	LEU234
A	TYR238

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11988089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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