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1J91

Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the ATP-competitive inhibitor 4,5,6,7-tetrabromobenzotriazole

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005829cellular_componentcytosol
A0005956cellular_componentprotein kinase CK2 complex
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006974biological_processDNA damage response
A0035175molecular_functionhistone H3S10 kinase activity
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035979molecular_functionhistone H2AXS139 kinase activity
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0051726biological_processregulation of cell cycle
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0106310molecular_functionprotein serine kinase activity
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A1990244molecular_functionhistone H2AT120 kinase activity
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004676molecular_function3-phosphoinositide-dependent protein kinase activity
B0004677molecular_functionDNA-dependent protein kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
B0004711molecular_functionribosomal protein S6 kinase activity
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005829cellular_componentcytosol
B0005956cellular_componentprotein kinase CK2 complex
B0006338biological_processchromatin remodeling
B0006468biological_processprotein phosphorylation
B0006974biological_processDNA damage response
B0035175molecular_functionhistone H3S10 kinase activity
B0035402molecular_functionhistone H3T11 kinase activity
B0035403molecular_functionhistone H3T6 kinase activity
B0035979molecular_functionhistone H2AXS139 kinase activity
B0044022molecular_functionhistone H3S28 kinase activity
B0044023molecular_functionhistone H4S1 kinase activity
B0044024molecular_functionhistone H2AS1 kinase activity
B0044025molecular_functionhistone H2BS14 kinase activity
B0051726biological_processregulation of cell cycle
B0072354molecular_functionhistone H3T3 kinase activity
B0072371molecular_functionhistone H2AS121 kinase activity
B0072518molecular_functionRho-dependent protein serine/threonine kinase activity
B0106310molecular_functionprotein serine kinase activity
B0140823molecular_functionhistone H2BS36 kinase activity
B0140855molecular_functionhistone H3S57 kinase activity
B0140857molecular_functionhistone H3T45 kinase activity
B1990244molecular_functionhistone H2AT120 kinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE TBS A 338
ChainResidue
AVAL45
AARG47
AVAL53
ALYS68
AHIS160
AILE174
AASP175
AHOH339

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE TBS B 338
ChainResidue
BVAL53
BLYS68
BHIS160
BMET163
BHOH339
BARG47

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFeGinvnnnek..........CIIK
ChainResidueDetails
AVAL45-LYS68

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
AILE152-ILE164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP156
BASP156

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AVAL45
ALYS68
BVAL45
BLYS68

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP156
AHIS160

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP156
BHIS160

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP156
ALYS158

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP156
BLYS158

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP156
ALYS158
ASER194

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP156
BLYS158
BSER194

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP156
AASN161
ALYS158

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP156
BASN161
BLYS158

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PDB entries from 2024-11-06

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