1J6T
COMPLEX OF ENZYME IIAMTL AND THE HISTIDINE-CONTAINING PHOSPHOCARRIER PROTEIN HPR FROM ESCHERICHIA COLI NMR, RESTRAINED REGULARIZED MEAN STRUCTURE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004857 | molecular_function | enzyme inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| B | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| B | 0030234 | molecular_function | enzyme regulator activity |
| B | 0043609 | biological_process | regulation of carbon utilization |
| B | 0045152 | molecular_function | antisigma factor binding |
| B | 0045819 | biological_process | positive regulation of glycogen catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00369 |
| Number of Residues | 8 |
| Details | PTS_HPR_HIS PTS HPR domain histidine phosphorylation site signature. GLHTRPAA |
| Chain | Residue | Details |
| B | GLY313-ALA320 |
| site_id | PS00372 |
| Number of Residues | 17 |
| Details | PTS_EIIA_TYPE_2_HIS PTS EIIA domains phosphorylation site signature 2. EkltptyLGesIAVPHG |
| Chain | Residue | Details |
| A | GLU50-GLY66 |
| site_id | PS00589 |
| Number of Residues | 16 |
| Details | PTS_HPR_SER PTS HPR domain serine phosphorylation site signature. GKsASaKSLFKLQtLG |
| Chain | Residue | Details |
| B | GLY339-GLY354 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000255|PROSITE-ProRule:PRU00681, ECO:0000269|PubMed:2261470 |
| Chain | Residue | Details |
| B | HIS315 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Stabilizes the transition state in the phosphoryl transfer from HPr to EIIA => ECO:0000269|PubMed:9551558 |
| Chain | Residue | Details |
| A | ARG49 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphohistidine; by HPr => ECO:0000269|PubMed:3142516, ECO:0000305|PubMed:12202490, ECO:0000305|PubMed:16443929, ECO:0000305|PubMed:2407724, ECO:0000305|PubMed:9551558 |
| Chain | Residue | Details |
| A | HIS65 |
