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1J4N

Crystal Structure of the AQP1 water channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0003097biological_processrenal water transport
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005267molecular_functionpotassium channel activity
A0005372molecular_functionwater transmembrane transporter activity
A0005634cellular_componentnucleus
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006833biological_processwater transport
A0006884biological_processcell volume homeostasis
A0006972biological_processhyperosmotic response
A0008519molecular_functionammonium channel activity
A0009925cellular_componentbasal plasma membrane
A0009992biological_processintracellular water homeostasis
A0015168molecular_functionglycerol transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0015670biological_processcarbon dioxide transport
A0015793biological_processglycerol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0019725biological_processcellular homeostasis
A0019934biological_processcGMP-mediated signaling
A0021670biological_processlateral ventricle development
A0022857molecular_functiontransmembrane transporter activity
A0030184molecular_functionnitric oxide transmembrane transporter activity
A0030185biological_processnitric oxide transport
A0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
A0031526cellular_componentbrush border membrane
A0031965cellular_componentnuclear membrane
A0032127cellular_componentdense core granule membrane
A0034644biological_processcellular response to UV
A0035377biological_processtransepithelial water transport
A0035378biological_processcarbon dioxide transmembrane transport
A0035379molecular_functioncarbon dioxide transmembrane transporter activity
A0042383cellular_componentsarcolemma
A0043066biological_processnegative regulation of apoptotic process
A0045177cellular_componentapical part of cell
A0045766biological_processpositive regulation of angiogenesis
A0046878biological_processpositive regulation of saliva secretion
A0048146biological_processpositive regulation of fibroblast proliferation
A0055085biological_processtransmembrane transport
A0070301biological_processcellular response to hydrogen peroxide
A0071260biological_processcellular response to mechanical stimulus
A0071280biological_processcellular response to copper ion
A0071288biological_processcellular response to mercury ion
A0071300biological_processcellular response to retinoic acid
A0071320biological_processcellular response to cAMP
A0071456biological_processcellular response to hypoxia
A0071472biological_processcellular response to salt stress
A0071474biological_processcellular hyperosmotic response
A0071549biological_processcellular response to dexamethasone stimulus
A0071805biological_processpotassium ion transmembrane transport
A0072488biological_processammonium transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A0170014cellular_componentankyrin-1 complex
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HLNPAVTLG
ChainResidueDetails
AHIS76-GLY84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues65
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
AMET1-LEU9
AVAL69-SER73
ACYS89-SER92
ATHR159-SER169
APHE231-LYS271

site_idSWS_FT_FI2
Number of Residues24
DetailsTRANSMEM: Helical; Name=Helix 1
ChainResidueDetails
APHE10-GLY34

site_idSWS_FT_FI3
Number of Residues50
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
APHE35-ASP50
ATHR118-GLY142
ATYR188-THR189
ATHR205-TRP215

site_idSWS_FT_FI4
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 2
ChainResidueDetails
AASN51-SER68

site_idSWS_FT_FI5
Number of Residues7
DetailsINTRAMEM:
ChainResidueDetails
AGLY74-ASN78
AGLY190-ILE193

site_idSWS_FT_FI6
Number of Residues9
DetailsINTRAMEM: Helical; Name=Helix B
ChainResidueDetails
APRO79-SER88

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=Helix 3
ChainResidueDetails
AVAL93-ILE117

site_idSWS_FT_FI8
Number of Residues15
DetailsTRANSMEM: Helical; Name=Helix 4
ChainResidueDetails
AILE143-THR158

site_idSWS_FT_FI9
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 5
ChainResidueDetails
AGLY170-ASP187

site_idSWS_FT_FI10
Number of Residues10
DetailsINTRAMEM: Helical; Name=Helix E
ChainResidueDetails
AASN194-ILE204

site_idSWS_FT_FI11
Number of Residues14
DetailsTRANSMEM: Helical; Name=Helix 6
ChainResidueDetails
AVAL216-ASP230

site_idSWS_FT_FI12
Number of Residues3
DetailsSITE: Substrate discrimination
ChainResidueDetails
APHE58
AHIS182
AARG197

site_idSWS_FT_FI13
Number of Residues1
DetailsSITE: Hg(2+)-sensitive residue
ChainResidueDetails
ACYS191

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q02013
ChainResidueDetails
ASER249
ASER264

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q02013
ChainResidueDetails
ATYR255

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN42

226707

PDB entries from 2024-10-30

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