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1J1B

Binary complex structure of human tau protein kinase I with AMPPNP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001837biological_processepithelial to mesenchymal transition
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002020molecular_functionprotease binding
A0002039molecular_functionp53 binding
A0003170biological_processheart valve development
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005977biological_processglycogen metabolic process
A0006468biological_processprotein phosphorylation
A0006983biological_processER overload response
A0007212biological_processdopamine receptor signaling pathway
A0007399biological_processnervous system development
A0007623biological_processcircadian rhythm
A0008013molecular_functionbeta-catenin binding
A0008286biological_processinsulin receptor signaling pathway
A0009968biological_processnegative regulation of signal transduction
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010822biological_processobsolete positive regulation of mitochondrion organization
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019082biological_processviral protein processing
A0019901molecular_functionprotein kinase binding
A0021766biological_processhippocampus development
A0030010biological_processestablishment of cell polarity
A0030011biological_processmaintenance of cell polarity
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030516biological_processregulation of axon extension
A0030877cellular_componentbeta-catenin destruction complex
A0031175biological_processneuron projection development
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031398biological_processpositive regulation of protein ubiquitination
A0031625molecular_functionubiquitin protein ligase binding
A0032007biological_processnegative regulation of TOR signaling
A0032092biological_processpositive regulation of protein binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032515biological_processnegative regulation of phosphoprotein phosphatase activity
A0032886biological_processregulation of microtubule-based process
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034452molecular_functiondynactin binding
A0035556biological_processintracellular signal transduction
A0036016biological_processcellular response to interleukin-3
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043547biological_processpositive regulation of GTPase activity
A0045597biological_processpositive regulation of cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045719biological_processnegative regulation of glycogen biosynthetic process
A0045724biological_processpositive regulation of cilium assembly
A0045732biological_processpositive regulation of protein catabolic process
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046777biological_processprotein autophosphorylation
A0046825biological_processregulation of protein export from nucleus
A0046827biological_processpositive regulation of protein export from nucleus
A0048156molecular_functiontau protein binding
A0048511biological_processrhythmic process
A0048814biological_processregulation of dendrite morphogenesis
A0050321molecular_functiontau-protein kinase activity
A0050770biological_processregulation of axonogenesis
A0051059molecular_functionNF-kappaB binding
A0051093biological_processnegative regulation of developmental process
A0051128biological_processregulation of cellular component organization
A0060070biological_processcanonical Wnt signaling pathway
A0060079biological_processexcitatory postsynaptic potential
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071109biological_processsuperior temporal gyrus development
A0071300biological_processcellular response to retinoic acid
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0106027biological_processneuron projection organization
A0106310molecular_functionprotein serine kinase activity
A0150101biological_processregulation of microtubule anchoring at centrosome
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1900271biological_processregulation of long-term synaptic potentiation
A1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A1901984biological_processnegative regulation of protein acetylation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903566biological_processpositive regulation of protein localization to cilium
A1904339biological_processnegative regulation of dopaminergic neuron differentiation
A1904646biological_processcellular response to amyloid-beta
A1904781biological_processpositive regulation of protein localization to centrosome
A1904886biological_processbeta-catenin destruction complex disassembly
A1990909cellular_componentWnt signalosome
A2000077biological_processnegative regulation of type B pancreatic cell development
A2000466biological_processnegative regulation of glycogen (starch) synthase activity
A2000740biological_processnegative regulation of mesenchymal stem cell differentiation
B0000166molecular_functionnucleotide binding
B0001837biological_processepithelial to mesenchymal transition
B0001954biological_processpositive regulation of cell-matrix adhesion
B0002020molecular_functionprotease binding
B0002039molecular_functionp53 binding
B0003170biological_processheart valve development
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005977biological_processglycogen metabolic process
B0006468biological_processprotein phosphorylation
B0006983biological_processER overload response
B0007212biological_processdopamine receptor signaling pathway
B0007399biological_processnervous system development
B0007623biological_processcircadian rhythm
B0008013molecular_functionbeta-catenin binding
B0008286biological_processinsulin receptor signaling pathway
B0009968biological_processnegative regulation of signal transduction
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010822biological_processobsolete positive regulation of mitochondrion organization
B0010975biological_processregulation of neuron projection development
B0010977biological_processnegative regulation of neuron projection development
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019082biological_processviral protein processing
B0019901molecular_functionprotein kinase binding
B0021766biological_processhippocampus development
B0030010biological_processestablishment of cell polarity
B0030011biological_processmaintenance of cell polarity
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030516biological_processregulation of axon extension
B0030877cellular_componentbeta-catenin destruction complex
B0031175biological_processneuron projection development
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031398biological_processpositive regulation of protein ubiquitination
B0031625molecular_functionubiquitin protein ligase binding
B0032007biological_processnegative regulation of TOR signaling
B0032092biological_processpositive regulation of protein binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032515biological_processnegative regulation of phosphoprotein phosphatase activity
B0032886biological_processregulation of microtubule-based process
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034452molecular_functiondynactin binding
B0035556biological_processintracellular signal transduction
B0036016biological_processcellular response to interleukin-3
B0042752biological_processregulation of circadian rhythm
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0043547biological_processpositive regulation of GTPase activity
B0045597biological_processpositive regulation of cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045719biological_processnegative regulation of glycogen biosynthetic process
B0045724biological_processpositive regulation of cilium assembly
B0045732biological_processpositive regulation of protein catabolic process
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046777biological_processprotein autophosphorylation
B0046825biological_processregulation of protein export from nucleus
B0046827biological_processpositive regulation of protein export from nucleus
B0048156molecular_functiontau protein binding
B0048511biological_processrhythmic process
B0048814biological_processregulation of dendrite morphogenesis
B0050321molecular_functiontau-protein kinase activity
B0050770biological_processregulation of axonogenesis
B0051059molecular_functionNF-kappaB binding
B0051093biological_processnegative regulation of developmental process
B0051128biological_processregulation of cellular component organization
B0060070biological_processcanonical Wnt signaling pathway
B0060079biological_processexcitatory postsynaptic potential
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071109biological_processsuperior temporal gyrus development
B0071300biological_processcellular response to retinoic acid
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0106027biological_processneuron projection organization
B0106310molecular_functionprotein serine kinase activity
B0150101biological_processregulation of microtubule anchoring at centrosome
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1900271biological_processregulation of long-term synaptic potentiation
B1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
B1901984biological_processnegative regulation of protein acetylation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903566biological_processpositive regulation of protein localization to cilium
B1904339biological_processnegative regulation of dopaminergic neuron differentiation
B1904646biological_processcellular response to amyloid-beta
B1904781biological_processpositive regulation of protein localization to centrosome
B1904886biological_processbeta-catenin destruction complex disassembly
B1990909cellular_componentWnt signalosome
B2000077biological_processnegative regulation of type B pancreatic cell development
B2000466biological_processnegative regulation of glycogen (starch) synthase activity
B2000740biological_processnegative regulation of mesenchymal stem cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE ANP A 430
ChainResidue
AILE62
ATYR134
AVAL135
AARG141
AGLN185
AASN186
ALEU188
AASP200
AHOH532
AHOH533
AHOH611
AASN64
AHOH621
AHOH638
AHOH644
AGLY65
APHE67
AVAL70
AALA83
ALYS85
AVAL110
AASP133

site_idAC2
Number of Residues25
DetailsBINDING SITE FOR RESIDUE ANP B 930
ChainResidue
BHOH44
BHOH135
BHOH184
BHOH193
BHOH257
BHOH300
BHOH333
BHOH363
BILE562
BGLY563
BASN564
BGLY565
BVAL570
BALA583
BLYS585
BVAL610
BASP633
BTYR634
BVAL635
BTHR638
BLYS683
BGLN685
BASN686
BLEU688
BASP700

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK
ChainResidueDetails
AILE62-LYS86

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL
ChainResidueDetails
AILE177-LEU189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP181
BASP681

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE62
BILE562

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006
ChainResidueDetails
ALYS85
BLYS585

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3 => ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:8250835
ChainResidueDetails
ASER9
BSER509

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422
ChainResidueDetails
ATYR216
BTYR716

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WV60
ChainResidueDetails
ASER389
BSER889

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR390
BTHR890

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ATHR402
BTHR902

218500

PDB entries from 2024-04-17

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