1IYI

Crystal structure of hematopoietic prostaglandin D synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004364	molecular_function	glutathione transferase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0007165	biological_process	signal transduction
A	0007626	biological_process	locomotory behavior
A	0019371	biological_process	cyclooxygenase pathway
A	0042803	molecular_function	protein homodimerization activity
B	0000287	molecular_function	magnesium ion binding
B	0004364	molecular_function	glutathione transferase activity
B	0004667	molecular_function	prostaglandin-D synthase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0007165	biological_process	signal transduction
B	0007626	biological_process	locomotory behavior
B	0019371	biological_process	cyclooxygenase pathway
B	0042803	molecular_function	protein homodimerization activity
C	0000287	molecular_function	magnesium ion binding
C	0004364	molecular_function	glutathione transferase activity
C	0004667	molecular_function	prostaglandin-D synthase activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0007165	biological_process	signal transduction
C	0007626	biological_process	locomotory behavior
C	0019371	biological_process	cyclooxygenase pathway
C	0042803	molecular_function	protein homodimerization activity
D	0000287	molecular_function	magnesium ion binding
D	0004364	molecular_function	glutathione transferase activity
D	0004667	molecular_function	prostaglandin-D synthase activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0007165	biological_process	signal transduction
D	0007626	biological_process	locomotory behavior
D	0019371	biological_process	cyclooxygenase pathway
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 1900

Chain	Residue
A	HOH1259
A	HOH1284
A	HOH1437
D	ASP696
D	HOH1908
D	HOH2009
D	HOH2030

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 1901

Chain	Residue
B	HOH1473
C	ASP496
C	HOH1988
C	HOH1989
C	HOH2004
B	HOH1432
B	HOH1433

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH A 1200

Chain	Residue
A	TYR8
A	ARG14
A	TRP39
A	LYS50
A	ILE51
A	GLN63
A	SER64
A	HOH1224
A	HOH1225
A	HOH1229
A	HOH1254
A	HOH1257
A	HOH1419
A	HOH1422
D	ASP697

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH B 1400

Chain	Residue
B	TYR208
B	ARG214
B	TRP239
B	LYS243
B	LYS250
B	ILE251
B	GLN263
B	SER264
B	HOH1427
B	HOH1431
B	HOH1458
B	HOH1461
B	HOH1510
B	HOH1517
C	ASP497

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GSH C 1600

Chain	Residue
B	ASP297
C	TYR408
C	ARG414
C	TRP439
C	LYS443
C	LYS450
C	ILE451
C	PRO452
C	GLN463
C	SER464
C	HOH1925
C	HOH1928
C	HOH2005
C	HOH2035
C	HOH2052
C	HOH2070

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GSH D 1800

Chain	Residue
A	ASP97
D	TYR608
D	ARG614
D	TRP639
D	LYS643
D	LYS650
D	ILE651
D	GLN663
D	SER664
D	HOH1910
D	HOH1960
D	HOH2015
D	HOH2017
D	HOH2043
D	HOH2068
D	HOH2119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	308
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	472
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR8

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
B	TYR208

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
C	TYR408

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
D	TYR608

---