Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1IY8

Crystal Structure of Levodione Reductase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity
E	0016491	molecular_function	oxidoreductase activity
F	0016491	molecular_function	oxidoreductase activity
G	0016491	molecular_function	oxidoreductase activity
H	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD A 1268

Chain	Residue
A	GLY20
A	ASN99
A	GLY101
A	THR150
A	SER152
A	TYR165
A	LYS169
A	PRO195
A	GLY196
A	THR200
A	PRO201
A	SER23
A	MET202
A	VAL203
A	MRD1269
A	HOH1272
A	HOH1328
A	GLY24
A	LEU25
A	ASP44
A	VAL45
A	ALA71
A	ASP72
A	VAL73

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD B 2268

Chain	Residue
B	GLY20
B	SER23
B	GLY24
B	LEU25
B	ASP44
B	VAL45
B	ALA71
B	ASP72
B	VAL73
B	ASN99
B	THR150
B	SER152
B	TYR165
B	LYS169
B	PRO195
B	GLY196
B	THR200
B	PRO201
B	MET202
B	VAL203
B	MRD2269
B	HOH2274
B	HOH2314

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD C 3268

Chain	Residue
C	GLY20
C	SER23
C	GLY24
C	LEU25
C	ASP44
C	VAL45
C	ALA71
C	ASP72
C	VAL73
C	ASN99
C	THR150
C	SER152
C	TYR165
C	LYS169
C	PRO195
C	GLY196
C	THR200
C	PRO201
C	MET202
C	VAL203
C	MRD3269
C	HOH3272
C	HOH3307
C	HOH3391

site_id	AC4
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD D 4268

Chain	Residue
D	GLY20
D	SER23
D	GLY24
D	LEU25
D	ASP44
D	VAL45
D	ALA71
D	ASP72
D	VAL73
D	ASN99
D	GLY101
D	THR150
D	SER152
D	TYR165
D	LYS169
D	PRO195
D	GLY196
D	THR200
D	PRO201
D	MET202
D	VAL203
D	MRD4269
D	HOH4283
D	HOH4364

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD E 5268

Chain	Residue
E	ASP44
E	VAL45
E	ALA71
E	ASP72
E	VAL73
E	ASN99
E	GLY101
E	THR150
E	SER152
E	TYR165
E	LYS169
E	PRO195
E	GLY196
E	THR200
E	PRO201
E	MET202
E	VAL203
E	MRD5269
E	HOH5273
E	HOH5360
E	GLY20
E	SER23
E	GLY24
E	LEU25

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD F 6268

Chain	Residue
F	GLY20
F	SER23
F	GLY24
F	LEU25
F	ASP44
F	VAL45
F	ALA71
F	ASP72
F	VAL73
F	ASN99
F	GLY101
F	THR150
F	SER152
F	TYR165
F	LYS169
F	PRO195
F	GLY196
F	THR200
F	PRO201
F	MET202
F	VAL203
F	MRD6269
F	HOH6272
F	HOH6348

site_id	AC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD G 7268

Chain	Residue
G	GLY20
G	GLY22
G	SER23
G	GLY24
G	LEU25
G	ASP44
G	VAL45
G	ALA71
G	ASP72
G	VAL73
G	ASN99
G	ILE123
G	THR150
G	SER152
G	TYR165
G	LYS169
G	PRO195
G	GLY196
G	THR200
G	PRO201
G	MET202
G	VAL203
G	MRD7269
G	HOH7280
G	HOH7324
G	HOH7383

site_id	AC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD H 8268

Chain	Residue
H	GLY20
H	SER23
H	GLY24
H	LEU25
H	ASP44
H	VAL45
H	ALA71
H	ASP72
H	VAL73
H	ASN99
H	ALA100
H	THR150
H	SER152
H	TYR165
H	LYS169
H	PRO195
H	GLY196
H	THR200
H	PRO201
H	MET202
H	VAL203
H	MRD8269
H	HOH8274
H	HOH8316
H	HOH8370

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 1269

Chain	Residue
A	GLU103
A	ILE159
A	GLN162
A	TYR165
A	NAD1268

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD B 2269

Chain	Residue
B	ILE159
B	GLN162
B	TYR165
B	NAD2268

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD C 3269

Chain	Residue
C	GLU103
C	ILE159
C	GLN162
C	TYR165
C	NAD3268

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD D 4269

Chain	Residue
D	GLU103
D	ILE159
D	GLN162
D	TYR165
D	NAD4268

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD E 5269

Chain	Residue
E	GLU103
E	ILE159
E	GLN162
E	TYR165
E	NAD5268

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD F 6269

Chain	Residue
F	GLU103
F	ILE159
F	GLN162
F	TYR165
F	SER206
F	NAD6268

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD G 7269

Chain	Residue
G	GLU103
G	ILE159
G	GLN162
G	TYR165
G	SER206
G	NAD7268

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD H 8269

Chain	Residue
H	GLU103
H	ILE159
H	GLN162
H	TYR165
H	NAD8268

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	200
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12621044","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Role in the determination of stereospecificity"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	SER152
A	LYS169
A	TYR165

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	SER152
B	LYS169
B	ASN124
B	TYR165

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	SER152
C	LYS169
C	ASN124
C	TYR165

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	SER152
D	LYS169
D	ASN124
D	TYR165

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
E	SER152
E	LYS169
E	ASN124
E	TYR165

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
F	SER152
F	LYS169
F	ASN124
F	TYR165

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
G	SER152
G	LYS169
G	ASN124
G	TYR165

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
H	SER152
H	LYS169
H	ASN124
H	TYR165

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS169
A	GLN162

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	LYS169
B	GLN162

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	LYS169
C	GLN162

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	SER152
B	LYS169
B	TYR165

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	LYS169
D	GLN162

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
E	LYS169
E	GLN162

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
F	LYS169
F	GLN162

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
G	LYS169
G	GLN162

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
H	LYS169
H	GLN162

site_id	CSA25
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS169
A	TYR165

site_id	CSA26
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	LYS169
B	TYR165

site_id	CSA27
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	LYS169
C	TYR165

site_id	CSA28
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	LYS169
D	TYR165

site_id	CSA29
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
E	LYS169
E	TYR165

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	SER152
C	LYS169
C	TYR165

site_id	CSA30
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
F	LYS169
F	TYR165

site_id	CSA31
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
G	LYS169
G	TYR165

site_id	CSA32
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
H	LYS169
H	TYR165

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	SER152
D	LYS169
D	TYR165

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
E	SER152
E	LYS169
E	TYR165

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
F	SER152
F	LYS169
F	TYR165

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
G	SER152
G	LYS169
G	TYR165

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
H	SER152
H	LYS169
H	TYR165

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	SER152
A	LYS169
A	ASN124
A	TYR165

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)