1IXQ
Enzyme-Phosphate2 Complex of Pyridoxine 5'-Phosphate synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008615 | biological_process | pyridoxine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016769 | molecular_function | transferase activity, transferring nitrogenous groups |
| A | 0033856 | molecular_function | pyridoxine 5'-phosphate synthase activity |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008615 | biological_process | pyridoxine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016769 | molecular_function | transferase activity, transferring nitrogenous groups |
| B | 0033856 | molecular_function | pyridoxine 5'-phosphate synthase activity |
| B | 0042802 | molecular_function | identical protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008615 | biological_process | pyridoxine biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016769 | molecular_function | transferase activity, transferring nitrogenous groups |
| C | 0033856 | molecular_function | pyridoxine 5'-phosphate synthase activity |
| C | 0042802 | molecular_function | identical protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008615 | biological_process | pyridoxine biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016769 | molecular_function | transferase activity, transferring nitrogenous groups |
| D | 0033856 | molecular_function | pyridoxine 5'-phosphate synthase activity |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1001 |
| Chain | Residue |
| A | ARG20 |
| A | GLY192 |
| A | HIS193 |
| A | GLY194 |
| A | LEU195 |
| A | ILE214 |
| A | GLY215 |
| A | HIS216 |
| A | HOH1020 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1002 |
| Chain | Residue |
| B | HIS193 |
| B | GLY194 |
| B | GLY215 |
| B | HIS216 |
| B | HOH1023 |
| C | ARG20 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1003 |
| Chain | Residue |
| B | ARG20 |
| C | GLY192 |
| C | HIS193 |
| C | GLY194 |
| C | ILE214 |
| C | GLY215 |
| C | HIS216 |
| C | HOH1005 |
| C | HOH1026 |
| C | HOH1028 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1004 |
| Chain | Residue |
| D | ARG20 |
| D | GLY192 |
| D | HIS193 |
| D | GLY194 |
| D | ASN213 |
| D | ILE214 |
| D | GLY215 |
| D | HIS216 |
| D | ALA217 |
| D | HOH1006 |
| D | HOH1007 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Transition state stabilizer"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 243 |
| Chain | Residue | Details |
| A | ASN9 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS12 | attractive charge-charge interaction, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS45 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ARG47 | attractive charge-charge interaction, electrostatic stabiliser, increase acidity, increase basicity |
| A | ARG51 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase acidity, increase basicity |
| A | GLU72 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | GLU153 | electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS193 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 243 |
| Chain | Residue | Details |
| B | ASN9 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS12 | attractive charge-charge interaction, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS45 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ARG47 | attractive charge-charge interaction, electrostatic stabiliser, increase acidity, increase basicity |
| B | ARG51 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase acidity, increase basicity |
| B | GLU72 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | GLU153 | electrostatic stabiliser, hydrogen bond acceptor |
| B | HIS193 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 8 |
| Details | M-CSA 243 |
| Chain | Residue | Details |
| C | ASN9 | electrostatic stabiliser, hydrogen bond donor |
| C | HIS12 | attractive charge-charge interaction, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | HIS45 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | ARG47 | attractive charge-charge interaction, electrostatic stabiliser, increase acidity, increase basicity |
| C | ARG51 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase acidity, increase basicity |
| C | GLU72 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | GLU153 | electrostatic stabiliser, hydrogen bond acceptor |
| C | HIS193 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 8 |
| Details | M-CSA 243 |
| Chain | Residue | Details |
| D | ASN9 | electrostatic stabiliser, hydrogen bond donor |
| D | HIS12 | attractive charge-charge interaction, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | HIS45 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | ARG47 | attractive charge-charge interaction, electrostatic stabiliser, increase acidity, increase basicity |
| D | ARG51 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase acidity, increase basicity |
| D | GLU72 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | GLU153 | electrostatic stabiliser, hydrogen bond acceptor |
| D | HIS193 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
