1IXE
Crystal structure of citrate synthase from Thermus thermophilus HB8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016740 | molecular_function | transferase activity |
| A | 0036440 | molecular_function | citrate synthase activity |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016740 | molecular_function | transferase activity |
| B | 0036440 | molecular_function | citrate synthase activity |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016740 | molecular_function | transferase activity |
| C | 0036440 | molecular_function | citrate synthase activity |
| C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016740 | molecular_function | transferase activity |
| D | 0036440 | molecular_function | citrate synthase activity |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 381 |
| Chain | Residue |
| B | ALA67 |
| B | ARG70 |
| B | ARG71 |
| C | ARG70 |
| C | ARG71 |
| C | HOH559 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 382 |
| Chain | Residue |
| B | ARG357 |
| B | PRO358 |
| B | GLY359 |
| B | ALA360 |
| A | ILE20 |
| A | GLY185 |
| A | PHE186 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 383 |
| Chain | Residue |
| A | ARG357 |
| A | PRO358 |
| A | GLY359 |
| A | ALA360 |
| B | CYS18 |
| B | ILE20 |
| B | GLY185 |
| B | PHE186 |
| B | HOH641 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 385 |
| Chain | Residue |
| B | ARG137 |
| B | LYS142 |
| B | ASN162 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 386 |
| Chain | Residue |
| D | ARG70 |
| D | ARG71 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 387 |
| Chain | Residue |
| A | ALA67 |
| A | ARG70 |
| A | ARG71 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 388 |
| Chain | Residue |
| C | ARG137 |
| C | LYS142 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 389 |
| Chain | Residue |
| C | ARG357 |
| C | GLY359 |
| C | ALA360 |
| D | ILE20 |
| D | GLY185 |
| D | PHE186 |
| D | HOH899 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 390 |
| Chain | Residue |
| C | ILE20 |
| C | GLY185 |
| C | PHE186 |
| C | HOH893 |
| D | ARG357 |
| D | GLY359 |
| D | ALA360 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 391 |
| Chain | Residue |
| A | ARG137 |
| A | LYS142 |
| A | ASN162 |
| A | HOH721 |
| D | ARG137 |
| D | LYS142 |
| D | GLY163 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE COA A 401 |
| Chain | Residue |
| A | ALA222 |
| A | ARG252 |
| A | ILE253 |
| A | GLY255 |
| A | MET256 |
| A | GLY257 |
| A | LYS262 |
| A | ARG305 |
| A | ILE307 |
| A | ASN310 |
| A | ASP312 |
| A | CIT405 |
| A | HOH502 |
| A | HOH788 |
| site_id | BC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE COA B 402 |
| Chain | Residue |
| A | ARG354 |
| B | ARG218 |
| B | ALA222 |
| B | ARG252 |
| B | ILE253 |
| B | GLY255 |
| B | MET256 |
| B | GLY257 |
| B | HIS258 |
| B | ARG259 |
| B | LEU302 |
| B | ILE307 |
| B | ASN310 |
| B | ASP312 |
| B | CIT406 |
| B | HOH528 |
| B | HOH601 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE COA C 403 |
| Chain | Residue |
| C | ARG218 |
| C | ALA222 |
| C | ARG252 |
| C | ILE253 |
| C | GLY255 |
| C | MET256 |
| C | GLY257 |
| C | HIS258 |
| C | ARG259 |
| C | LEU302 |
| C | ASN310 |
| C | ASP312 |
| C | CIT407 |
| C | HOH769 |
| D | ARG354 |
| site_id | BC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE COA D 404 |
| Chain | Residue |
| C | ARG354 |
| C | LEU355 |
| D | GLU8 |
| D | ARG218 |
| D | ARG252 |
| D | ILE253 |
| D | GLY255 |
| D | MET256 |
| D | GLY257 |
| D | HIS258 |
| D | ARG259 |
| D | LEU302 |
| D | ILE307 |
| D | ASN310 |
| D | ASP312 |
| D | CIT408 |
| D | HOH801 |
| D | HOH802 |
| D | HOH944 |
| site_id | BC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT A 405 |
| Chain | Residue |
| A | HIS184 |
| A | ASN187 |
| A | HIS219 |
| A | GLY220 |
| A | HIS258 |
| A | ARG267 |
| A | ASP312 |
| A | ARG337 |
| A | COA401 |
| A | HOH501 |
| A | HOH503 |
| B | ARG357 |
| site_id | BC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CIT B 406 |
| Chain | Residue |
| A | ARG357 |
| B | HIS184 |
| B | ASN187 |
| B | HIS219 |
| B | GLY220 |
| B | HIS258 |
| B | ARG267 |
| B | VAL311 |
| B | ASP312 |
| B | PHE333 |
| B | ARG337 |
| B | COA402 |
| B | HOH602 |
| B | HOH603 |
| site_id | BC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CIT C 407 |
| Chain | Residue |
| C | HIS184 |
| C | ASN187 |
| C | HIS219 |
| C | GLY220 |
| C | HIS258 |
| C | ARG267 |
| C | ASP312 |
| C | PHE333 |
| C | ARG337 |
| C | COA403 |
| C | HOH702 |
| C | HOH703 |
| D | ARG357 |
| site_id | BC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT D 408 |
| Chain | Residue |
| C | ARG357 |
| D | HIS184 |
| D | ASN187 |
| D | HIS219 |
| D | HIS258 |
| D | ARG267 |
| D | ASP312 |
| D | PHE333 |
| D | ARG337 |
| D | COA404 |
| D | HOH802 |
| D | HOH803 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 411 |
| Chain | Residue |
| A | TYR30 |
| A | LEU51 |
| A | HIS52 |
| A | ARG114 |
| A | LEU346 |
| A | GLU347 |
| A | GLU350 |
| A | HOH891 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 412 |
| Chain | Residue |
| B | TYR30 |
| B | LEU51 |
| B | HIS52 |
| B | GLY53 |
| B | ARG114 |
| B | LEU346 |
| B | GLU347 |
| B | GLU350 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 413 |
| Chain | Residue |
| C | ARG16 |
| C | TYR30 |
| C | LEU51 |
| C | HIS52 |
| C | ARG114 |
| C | LEU346 |
| C | GLU347 |
| C | GLU350 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 414 |
| Chain | Residue |
| D | LEU51 |
| D | HIS52 |
| D | ARG114 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | HIS219 | |
| A | HIS258 | |
| A | ASP312 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | HIS219 | |
| B | HIS258 | |
| B | ASP312 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| C | HIS219 | |
| C | HIS258 | |
| C | ASP312 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| D | HIS219 | |
| D | HIS258 | |
| D | ASP312 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | SER189 | |
| A | HIS258 | |
| A | HIS219 | |
| A | ASP312 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | SER189 | |
| B | HIS258 | |
| B | HIS219 | |
| B | ASP312 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| C | SER189 | |
| C | HIS258 | |
| C | HIS219 | |
| C | ASP312 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| D | SER189 | |
| D | HIS258 | |
| D | HIS219 | |
| D | ASP312 |
