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1IX4

Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Carbon Monoxide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001666biological_processresponse to hypoxia
A0002246biological_processwound healing involved in inflammatory response
A0004392molecular_functionheme oxygenase (decyclizing) activity
A0004630molecular_functionphospholipase D activity
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005901cellular_componentcaveola
A0006357biological_processregulation of transcription by RNA polymerase II
A0006644biological_processphospholipid metabolic process
A0006788biological_processheme oxidation
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007264biological_processsmall GTPase-mediated signal transduction
A0008217biological_processregulation of blood pressure
A0008285biological_processnegative regulation of cell population proliferation
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0009410biological_processresponse to xenobiotic stimulus
A0010656biological_processnegative regulation of muscle cell apoptotic process
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016239biological_processpositive regulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016491molecular_functionoxidoreductase activity
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0031670biological_processcellular response to nutrient
A0032764biological_processnegative regulation of mast cell cytokine production
A0034101biological_processerythrocyte homeostasis
A0034605biological_processcellular response to heat
A0035094biological_processresponse to nicotine
A0035556biological_processintracellular signal transduction
A0042167biological_processheme catabolic process
A0042168biological_processheme metabolic process
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043305biological_processnegative regulation of mast cell degranulation
A0043524biological_processnegative regulation of neuron apoptotic process
A0043627biological_processresponse to estrogen
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0052869molecular_functionarachidonate omega-hydroxylase activity
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0071243biological_processcellular response to arsenic-containing substance
A0071276biological_processcellular response to cadmium ion
A0072719biological_processcellular response to cisplatin
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0097421biological_processliver regeneration
A0110076biological_processnegative regulation of ferroptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1904019biological_processepithelial cell apoptotic process
A1904036biological_processnegative regulation of epithelial cell apoptotic process
A1904037biological_processpositive regulation of epithelial cell apoptotic process
A1904550biological_processresponse to arachidonate
A1904681biological_processresponse to 3-methylcholanthrene
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE HEM A 300
ChainResidue
ALYS18
ASER142
AGLY143
ALEU147
AARG183
APHE207
AASN210
APHE214
ACMO1001
AHOH1018
AHOH1078
AHIS25
AHOH1150
AGLU29
AMET34
AGLN38
ATYR134
ATHR135
AARG136
AGLY139

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CMO A 1001
ChainResidue
AGLY139
AGLY143
AGLY144
AHEM300
AHOH1108

Functional Information from PROSITE/UniProt
site_idPS00593
Number of Residues11
DetailsHEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG
ChainResidueDetails
ALEU129-GLY139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues265
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
AMET1-THR266

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
ALYS18
ATYR134
AARG183

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
AHIS25

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Important for catalytic activity => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
AASP140

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
ASER229

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER242

Catalytic Information from CSA
site_idCSA1
Number of Residues7
DetailsAnnotated By Reference To The Literature 1dve
ChainResidueDetails
AARG136
ATYR58
ATHR135
AASP140
AGLY143
AHIS25
AGLY139

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1dve
ChainResidueDetails
AASP140
AGLY144

227111

PDB entries from 2024-11-06

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