1IWE
IMP Complex of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0004019 | molecular_function | adenylosuccinate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006163 | biological_process | purine nucleotide metabolic process |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006167 | biological_process | AMP biosynthetic process |
| A | 0006531 | biological_process | aspartate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0044209 | biological_process | AMP salvage |
| A | 0046040 | biological_process | IMP metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051015 | molecular_function | actin filament binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0004019 | molecular_function | adenylosuccinate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006163 | biological_process | purine nucleotide metabolic process |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006167 | biological_process | AMP biosynthetic process |
| B | 0006531 | biological_process | aspartate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0044209 | biological_process | AMP salvage |
| B | 0046040 | biological_process | IMP metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051015 | molecular_function | actin filament binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1442 |
| Chain | Residue |
| B | GLY70 |
| B | HOH575 |
| B | HOH903 |
| B | HOH904 |
| B | HOH936 |
| B | IMP1452 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 458 |
| Chain | Residue |
| A | LYS46 |
| A | HIS71 |
| A | HOH774 |
| A | HOH855 |
| A | ASP43 |
| A | GLU44 |
| A | GLY45 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 459 |
| Chain | Residue |
| A | GLY330 |
| A | VAL331 |
| A | THR332 |
| A | THR333 |
| A | ARG335 |
| A | IMP460 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE IMP B 1443 |
| Chain | Residue |
| A | ARG177 |
| B | TRP41 |
| B | ASP43 |
| B | ASN68 |
| B | ILE160 |
| B | GLY161 |
| B | THR162 |
| B | THR163 |
| B | ILE167 |
| B | PHE269 |
| B | VAL270 |
| B | THR271 |
| B | VAL305 |
| B | HOH563 |
| B | HOH693 |
| B | HOH719 |
| B | HOH832 |
| B | HOH861 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE IMP B 1452 |
| Chain | Residue |
| B | GLU44 |
| B | GLY45 |
| B | LYS46 |
| B | GLY47 |
| B | LYS48 |
| B | GLY70 |
| B | HIS71 |
| B | THR72 |
| B | LYS363 |
| B | ASP365 |
| B | GLY445 |
| B | VAL446 |
| B | GLY447 |
| B | LYS448 |
| B | HOH555 |
| B | HOH620 |
| B | HOH627 |
| B | HOH724 |
| B | HOH936 |
| B | MG1442 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE IMP A 460 |
| Chain | Residue |
| A | ASP43 |
| A | ASN68 |
| A | ALA69 |
| A | ILE160 |
| A | GLY161 |
| A | THR162 |
| A | THR163 |
| A | ASN256 |
| A | LEU260 |
| A | VAL270 |
| A | THR271 |
| A | VAL305 |
| A | ARG335 |
| A | ACT459 |
| A | HOH507 |
| A | HOH529 |
| A | HOH538 |
| A | HOH547 |
| A | HOH588 |
| A | HOH774 |
| B | ARG177 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03126 |
| Chain | Residue | Details |
| A | ASP43 | |
| B | ASP43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_03126 |
| Chain | Residue | Details |
| A | HIS71 | |
| B | HIS71 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03126, ECO:0000269|PubMed:12004071 |
| Chain | Residue | Details |
| A | GLY42 | |
| B | GLY445 | |
| A | ARG177 | |
| A | ARG337 | |
| A | LYS363 | |
| A | GLY445 | |
| B | GLY42 | |
| B | ARG177 | |
| B | ARG337 | |
| B | LYS363 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP43 | |
| A | GLY70 | |
| A | VAL331 | |
| B | ASP43 | |
| B | GLY70 | |
| B | VAL331 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: in other chain |
| Chain | Residue | Details |
| A | ASN68 | |
| B | ASN68 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03126, ECO:0000269|PubMed:12004071 |
| Chain | Residue | Details |
| A | THR163 | |
| A | ASN256 | |
| A | THR271 | |
| A | ARG335 | |
| B | THR163 | |
| B | ASN256 | |
| B | THR271 | |
| B | ARG335 |
