1IVY
PHYSIOLOGICAL DIMER HPP PRECURSOR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0004185 | molecular_function | serine-type carboxypeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006508 | biological_process | proteolysis |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098575 | cellular_component | lumenal side of lysosomal membrane |
| A | 1904714 | biological_process | regulation of chaperone-mediated autophagy |
| A | 1904715 | biological_process | negative regulation of chaperone-mediated autophagy |
| B | 0004180 | molecular_function | carboxypeptidase activity |
| B | 0004185 | molecular_function | serine-type carboxypeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006508 | biological_process | proteolysis |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0031647 | biological_process | regulation of protein stability |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098575 | cellular_component | lumenal side of lysosomal membrane |
| B | 1904714 | biological_process | regulation of chaperone-mediated autophagy |
| B | 1904715 | biological_process | negative regulation of chaperone-mediated autophagy |
Functional Information from PDB Data
| site_id | CAT |
| Number of Residues | 6 |
| Details | CATALYTIC TRIAD SERINE CARBOXYPEPTIDASE. |
| Chain | Residue |
| A | SER150 |
| A | ASP372 |
| A | HIS429 |
| B | SER150 |
| B | ASP372 |
| B | HIS429 |
Functional Information from PROSITE/UniProt
| site_id | PS00131 |
| Number of Residues | 8 |
| Details | CARBOXYPEPT_SER_SER Serine carboxypeptidases, serine active site. LtGESYAG |
| Chain | Residue | Details |
| A | LEU146-GLY153 |
| site_id | PS00560 |
| Number of Residues | 18 |
| Details | CARBOXYPEPT_SER_HIS Serine carboxypeptidases, histidine active site. IafLtIkGAGHmVPtdkP |
| Chain | Residue | Details |
| A | ILE419-PRO436 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bcr |
| Chain | Residue | Details |
| A | ASP372 | |
| A | HIS429 | |
| B | TYR151 | |
| B | GLY57 | |
| B | SER150 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bcr |
| Chain | Residue | Details |
| A | ASP372 | |
| A | TYR151 | |
| A | HIS429 | |
| A | GLY57 | |
| A | SER150 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bcr |
| Chain | Residue | Details |
| B | ASP372 | |
| B | TYR151 | |
| B | HIS429 | |
| B | GLY57 | |
| B | SER150 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bcr |
| Chain | Residue | Details |
| A | ASP372 | |
| A | HIS429 | |
| A | SER150 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bcr |
| Chain | Residue | Details |
| B | ASP372 | |
| B | HIS429 | |
| B | SER150 |
