1IVJ

Crystal Structure of Rat Hemeoxygenase-1 in Complex with Heme and Azide.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001666	biological_process	response to hypoxia
A	0004392	molecular_function	heme oxygenase (decyclizing) activity
A	0004630	molecular_function	D-type glycerophospholipase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006644	biological_process	phospholipid metabolic process
A	0006788	biological_process	heme oxidation
A	0006979	biological_process	response to oxidative stress
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0008217	biological_process	regulation of blood pressure
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0009410	biological_process	response to xenobiotic stimulus
A	0010656	biological_process	negative regulation of muscle cell apoptotic process
A	0019899	molecular_function	enzyme binding
A	0020037	molecular_function	heme binding
A	0031670	biological_process	cellular response to nutrient
A	0032764	biological_process	negative regulation of mast cell cytokine production
A	0035556	biological_process	intracellular signal transduction
A	0042167	biological_process	heme catabolic process
A	0042542	biological_process	response to hydrogen peroxide
A	0043305	biological_process	negative regulation of mast cell degranulation
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0043627	biological_process	response to estrogen
A	0045766	biological_process	positive regulation of angiogenesis
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0052869	molecular_function	arachidonate omega-hydroxylase activity
A	0097421	biological_process	liver regeneration
A	0110076	biological_process	negative regulation of ferroptosis
A	1904036	biological_process	negative regulation of epithelial cell apoptotic process
A	1904550	biological_process	response to arachidonate
A	1904681	biological_process	response to 3-methylcholanthrene
A	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AZI A 1001

Chain	Residue
A	GLY139
A	SER142
A	GLY143
A	GLY144
A	HEM300
A	HOH1126

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE AZI A 1002

Chain	Residue
A	ARG27

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM A 300

Chain	Residue
A	GLU29
A	MET34
A	GLN38
A	TYR134
A	THR135
A	ARG136
A	GLY139
A	SER142
A	GLY143
A	LEU147
A	LYS179
A	ARG183
A	PHE207
A	ASN210
A	AZI1001
A	HOH1004
A	HOH1011
A	HOH1110
A	HOH1147
A	HOH1152
A	LYS18
A	HIS25

---

Functional Information from PROSITE/UniProt

site_id	PS00593
Number of Residues	11
Details	HEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG

Chain	Residue	Details
A	LEU129-GLY139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P09601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P09601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"UniProtKB","id":"P09601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	7
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
A	ARG136
A	TYR58
A	THR135
A	ASP140
A	GLY143
A	HIS25
A	GLY139

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
A	ASP140
A	GLY144

---