1IV1

Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0046872	molecular_function	metal ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0046872	molecular_function	metal ion binding
C	0008299	biological_process	isoprenoid biosynthetic process
C	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0046872	molecular_function	metal ion binding
D	0008299	biological_process	isoprenoid biosynthetic process
D	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D	0016114	biological_process	terpenoid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
D	0046872	molecular_function	metal ion binding
E	0008299	biological_process	isoprenoid biosynthetic process
E	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E	0016114	biological_process	terpenoid biosynthetic process
E	0016829	molecular_function	lyase activity
E	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
E	0046872	molecular_function	metal ion binding
F	0008299	biological_process	isoprenoid biosynthetic process
F	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F	0016114	biological_process	terpenoid biosynthetic process
F	0016829	molecular_function	lyase activity
F	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
F	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDAAlHAltDAllS

Chain	Residue	Details
A	SER35-SER50

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00107

Chain	Residue	Details
A	ASP8
C	HIS242
C	ASP256
C	PHE261
D	ASP408
D	HIS410
D	HIS434
D	HIS442
D	ASP456
D	PHE461
B	ASP1008
A	HIS10
B	HIS1010
B	HIS1034
B	HIS1042
B	ASP1056
B	PHE1061
E	ASP1208
E	HIS1210
E	HIS1234
E	HIS1242
E	ASP1256
A	HIS34
E	PHE1261
F	ASP1408
F	HIS1410
F	HIS1434
F	HIS1442
F	ASP1456
F	PHE1461
A	HIS42
A	ASP56
A	PHE61
C	ASP208
C	HIS210
C	HIS234

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LEU100
E	PHE1331
F	LEU1500
F	PHE1531
A	PHE131
C	LEU300
C	PHE331
D	LEU500
D	PHE531
B	LEU1100
B	PHE1131
E	LEU1300

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site_id	SWS_FT_FI3
Number of Residues	12
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00107

Chain	Residue	Details
A	HIS34
E	THR1333
F	HIS1434
F	THR1533
A	THR133
C	HIS234
C	THR333
D	HIS434
D	THR533
B	HIS1034
B	THR1133
E	HIS1234

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