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1ITU

HUMAN RENAL DIPEPTIDASE COMPLEXED WITH CILASTATIN

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006629biological_processlipid metabolic process
A0006691biological_processleukotriene metabolic process
A0006749biological_processglutathione metabolic process
A0006751biological_processglutathione catabolic process
A0006954biological_processinflammatory response
A0008235molecular_functionmetalloexopeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0008800molecular_functionbeta-lactamase activity
A0016324cellular_componentapical plasma membrane
A0016805molecular_functiondipeptidase activity
A0016999biological_processantibiotic metabolic process
A0030054cellular_componentcell junction
A0030336biological_processnegative regulation of cell migration
A0030593biological_processneutrophil chemotaxis
A0031528cellular_componentmicrovillus membrane
A0034235molecular_functionGPI anchor binding
A0042995cellular_componentcell projection
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045177cellular_componentapical part of cell
A0046872molecular_functionmetal ion binding
A0050667biological_processhomocysteine metabolic process
A0070062cellular_componentextracellular exosome
A0070573molecular_functionmetallodipeptidase activity
A0071277biological_processcellular response to calcium ion
A0071466biological_processcellular response to xenobiotic stimulus
A0071732biological_processcellular response to nitric oxide
A0072340biological_processlactam catabolic process
A0072341molecular_functionmodified amino acid binding
A0098552cellular_componentside of membrane
A1901749biological_processleukotriene D4 catabolic process
A2000117biological_processnegative regulation of cysteine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006629biological_processlipid metabolic process
B0006691biological_processleukotriene metabolic process
B0006749biological_processglutathione metabolic process
B0006751biological_processglutathione catabolic process
B0006954biological_processinflammatory response
B0008235molecular_functionmetalloexopeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0008800molecular_functionbeta-lactamase activity
B0016324cellular_componentapical plasma membrane
B0016805molecular_functiondipeptidase activity
B0016999biological_processantibiotic metabolic process
B0030054cellular_componentcell junction
B0030336biological_processnegative regulation of cell migration
B0030593biological_processneutrophil chemotaxis
B0031528cellular_componentmicrovillus membrane
B0034235molecular_functionGPI anchor binding
B0042995cellular_componentcell projection
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0045177cellular_componentapical part of cell
B0046872molecular_functionmetal ion binding
B0050667biological_processhomocysteine metabolic process
B0070062cellular_componentextracellular exosome
B0070573molecular_functionmetallodipeptidase activity
B0071277biological_processcellular response to calcium ion
B0071466biological_processcellular response to xenobiotic stimulus
B0071732biological_processcellular response to nitric oxide
B0072340biological_processlactam catabolic process
B0072341molecular_functionmodified amino acid binding
B0098552cellular_componentside of membrane
B1901749biological_processleukotriene D4 catabolic process
B2000117biological_processnegative regulation of cysteine-type endopeptidase activity
Functional Information from PROSITE/UniProt
site_idPS00869
Number of Residues23
DetailsRENAL_DIPEPTIDASE_1 Renal dipeptidase active site. VEGGhsIdsslgvLralYqlGMR
ChainResidueDetails
AVAL124-ARG146

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777
ChainResidueDetails
AHIS20
AASP22
AHIS198
AHIS219
BHIS20
BASP22
BHIS198
BHIS219

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:32325220
ChainResidueDetails
AGLU125
BGLU125

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:12144777
ChainResidueDetails
AHIS152
AARG230
AASP288
BHIS152
BARG230
BASP288

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:2168407
ChainResidueDetails
ASER369
BSER369

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN41
BASN41

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN263
BASN263

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777
ChainResidueDetails
AASN316
BASN316

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN342
BASN342

Catalytic Information from CSA
site_idMCSA1
Number of Residues7
DetailsM-CSA 168
ChainResidueDetails
AHIS20metal ligand
AASP22metal ligand
AGLU125metal ligand
AHIS152electrostatic stabiliser, hydrogen bond donor
AHIS198metal ligand
AHIS219metal ligand
AASP288hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_idMCSA2
Number of Residues7
DetailsM-CSA 168
ChainResidueDetails
BHIS20metal ligand
BASP22metal ligand
BGLU125metal ligand
BHIS152electrostatic stabiliser, hydrogen bond donor
BHIS198metal ligand
BHIS219metal ligand
BASP288hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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PDB entries from 2024-11-06

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