Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070301 | biological_process | cellular response to hydrogen peroxide |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 732 |
| Chain | Residue |
| A | GLN239 |
| A | ARG243 |
| A | HOH2349 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 733 |
| Chain | Residue |
| A | PRO282 |
| A | ILE283 |
| B | ARG684 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 734 |
| Chain | Residue |
| A | ARG594 |
| A | LYS580 |
| A | ILE592 |
| A | THR593 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 735 |
| Chain | Residue |
| A | ARG684 |
| A | HOH2724 |
| B | PRO282 |
| B | ILE283 |
| B | HOH2473 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 732 |
| Chain | Residue |
| B | GLN239 |
| B | ARG243 |
| B | HOH2372 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 733 |
| Chain | Residue |
| B | LYS580 |
| B | ILE592 |
| B | THR593 |
| B | ARG594 |
| B | HOH2192 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 2001 |
| Chain | Residue |
| A | SER212 |
| A | ASN220 |
| A | PRO224 |
| A | ASN236 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 2002 |
| Chain | Residue |
| A | SER612 |
| B | GLY44 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 2003 |
| Chain | Residue |
| A | GLY44 |
| B | SER612 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 2004 |
| Chain | Residue |
| A | VAL581 |
| A | ASP582 |
| A | GLY583 |
| A | ASN603 |
| A | HOH2155 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 2005 |
| Chain | Residue |
| A | TRP331 |
| A | LYS376 |
| A | ARG377 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL A 2006 |
| Chain | Residue |
| A | PRO566 |
| A | GLU567 |
| A | THR569 |
| A | ALA571 |
| A | PRO572 |
| A | HOH2086 |
| A | HOH2319 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 2007 |
| Chain | Residue |
| A | TRP187 |
| B | LYS21 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 2008 |
| Chain | Residue |
| A | LYS710 |
| B | GLU47 |
| B | GLN145 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 2009 |
| Chain | Residue |
| A | GLU47 |
| A | GLN145 |
| A | HOH2591 |
| B | LYS710 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 2010 |
| Chain | Residue |
| A | LYS21 |
| B | TRP187 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 2011 |
| Chain | Residue |
| A | GLU491 |
| A | GLU491 |
| A | HOH2129 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 2012 |
| Chain | Residue |
| A | GLY481 |
| A | ARG487 |
| A | PHE574 |
| A | HOH2057 |
| A | HOH2062 |
| A | HOH2169 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 2013 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 2014 |
| Chain | Residue |
| A | ASN220 |
| A | HOH2044 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 2015 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 2016 |
| Chain | Residue |
| B | VAL581 |
| B | ASP582 |
| B | GLY583 |
| B | ASN603 |
| B | HOH2256 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 2017 |
| Chain | Residue |
| A | TRP429 |
| A | HOH2095 |
| A | HOH2632 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 2018 |
| Chain | Residue |
| B | SER212 |
| B | ASN220 |
| B | PRO224 |
| B | ASN236 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE UNX B 2019 |
| Chain | Residue |
| B | GLY481 |
| B | ARG487 |
| B | PHE574 |
| B | HOH2046 |
| B | HOH2160 |
| B | HOH2165 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 2020 |
| Chain | Residue |
| B | TRP331 |
| B | LYS376 |
| B | ARG377 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 2021 |
| Chain | Residue |
| B | VAL213 |
| B | ASN220 |
| B | HOH2148 |
| B | HOH2301 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 2022 |
| Chain | Residue |
| B | MET427 |
| B | TRP429 |
| B | HOH2227 |
| site_id | DC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM A 800 |
| Chain | Residue |
| A | LEU89 |
| A | ARG92 |
| A | TRP95 |
| A | PRO221 |
| A | LEU254 |
| A | ILE255 |
| A | GLY258 |
| A | HIS259 |
| A | PHE261 |
| A | GLY262 |
| A | LYS263 |
| A | VAL264 |
| A | HIS265 |
| A | THR304 |
| A | SER305 |
| A | TRP311 |
| A | THR371 |
| A | TRP403 |
| A | HOH2019 |
| A | HOH2071 |
| A | HOH2102 |
| A | HOH2645 |
| A | PRO88 |
| site_id | DC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM B 800 |
| Chain | Residue |
| B | PRO88 |
| B | TRP95 |
| B | PRO221 |
| B | LEU254 |
| B | ILE255 |
| B | GLY258 |
| B | HIS259 |
| B | GLY262 |
| B | LYS263 |
| B | VAL264 |
| B | HIS265 |
| B | THR304 |
| B | SER305 |
| B | TRP311 |
| B | THR371 |
| B | PHE399 |
| B | TRP403 |
| B | HOH2042 |
| B | HOH2117 |
| B | HOH2210 |
Functional Information from PROSITE/UniProt
| site_id | PS00435 |
| Number of Residues | 11 |
| Details | PEROXIDASE_1 Peroxidases proximal heme-ligand signature. TAALIAGGHTF |
| Chain | Residue | Details |
| A | THR251-PHE261 | |
| site_id | PS00436 |
| Number of Residues | 12 |
| Details | PEROXIDASE_2 Peroxidases active site signature. GPlfIRMaWHSA |
| Chain | Residue | Details |
| A | GLY87-ALA98 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)"} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1apx |
| Chain | Residue | Details |
| A | ARG92 | |
| A | HIS96 | |
| A | ASP125 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1apx |
| Chain | Residue | Details |
| B | ARG92 | |
| B | HIS96 | |
| B | ASP125 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1apx |
| Chain | Residue | Details |
| A | ASN126 | |
| A | ARG92 | |
| A | HIS96 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1apx |
| Chain | Residue | Details |
| B | ASN126 | |
| B | ARG92 | |
| B | HIS96 | |
