1IRD
Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005344 | molecular_function | oxygen carrier activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005829 | cellular_component | cytosol |
| A | 0005833 | cellular_component | hemoglobin complex |
| A | 0015670 | biological_process | carbon dioxide transport |
| A | 0015671 | biological_process | oxygen transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030185 | biological_process | nitric oxide transport |
| A | 0031720 | molecular_function | haptoglobin binding |
| A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0043177 | molecular_function | organic acid binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071682 | cellular_component | endocytic vesicle lumen |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005344 | molecular_function | oxygen carrier activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005829 | cellular_component | cytosol |
| B | 0005833 | cellular_component | hemoglobin complex |
| B | 0008217 | biological_process | regulation of blood pressure |
| B | 0015670 | biological_process | carbon dioxide transport |
| B | 0015671 | biological_process | oxygen transport |
| B | 0019825 | molecular_function | oxygen binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030185 | biological_process | nitric oxide transport |
| B | 0030492 | molecular_function | hemoglobin binding |
| B | 0031720 | molecular_function | haptoglobin binding |
| B | 0031721 | molecular_function | hemoglobin alpha binding |
| B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0043177 | molecular_function | organic acid binding |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070293 | biological_process | renal absorption |
| B | 0070527 | biological_process | platelet aggregation |
| B | 0071682 | cellular_component | endocytic vesicle lumen |
| B | 0072562 | cellular_component | blood microparticle |
| B | 0097746 | biological_process | blood vessel diameter maintenance |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM A 142 |
| Chain | Residue |
| A | TYR42 |
| A | VAL93 |
| A | ASN97 |
| A | PHE98 |
| A | LEU101 |
| A | LEU136 |
| A | CMO143 |
| A | HOH2134 |
| A | HOH2138 |
| A | HOH2214 |
| A | HOH2215 |
| A | PHE43 |
| A | HOH2259 |
| A | HIS45 |
| A | HIS58 |
| A | LYS61 |
| A | LEU83 |
| A | LEU86 |
| A | HIS87 |
| A | LEU91 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CMO A 143 |
| Chain | Residue |
| A | LEU29 |
| A | HIS58 |
| A | VAL62 |
| A | HEM142 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM B 347 |
| Chain | Residue |
| A | PRO4 |
| A | HOH2163 |
| A | HOH2235 |
| B | THR238 |
| B | PHE241 |
| B | PHE242 |
| B | HIS263 |
| B | LYS266 |
| B | PHE271 |
| B | LEU288 |
| B | HIS292 |
| B | LEU296 |
| B | ASN302 |
| B | LEU341 |
| B | CMO348 |
| B | HOH2035 |
| B | HOH2036 |
| B | HOH2082 |
| B | HOH2111 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CMO B 348 |
| Chain | Residue |
| B | HIS263 |
| B | VAL267 |
| B | HEM347 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00238 |
| Chain | Residue | Details |
| A | GLY59 | |
| B | LEU203 | |
| B | GLY283 | |
| B | LYS344 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: proximal binding residue => ECO:0000255|PROSITE-ProRule:PRU00238 |
| Chain | Residue | Details |
| A | ALA88 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 |
| Chain | Residue | Details |
| A | ASN9 | |
| A | ARG92 | |
| A | VAL107 | |
| A | LEU109 | |
| A | HIS122 | |
| A | THR134 | |
| A | TRP14 | |
| A | GLY25 | |
| A | GLU30 | |
| A | PHE46 | |
| A | LEU48 | |
| A | ALA53 | |
| A | LYS56 | |
| A | LYS60 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| A | ALA12 | |
| B | LEU275 | |
| B | PHE285 | |
| B | CYS293 | |
| B | LEU305 | |
| B | VAL311 | |
| B | LYS320 | |
| B | THR323 | |
| B | ALA329 | |
| B | LEU341 | |
| B | TYR345 | |
| A | GLY57 | |
| A | LYS61 | |
| A | LEU91 | |
| A | LEU100 | |
| B | GLY246 | |
| B | ALA253 | |
| B | ASN257 | |
| B | SER272 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | PRO4 | |
| A | PHE36 | |
| A | HIS50 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| A | THR8 | |
| A | VAL17 | |
| A | THR41 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | ASN9 | |
| B | PHE245 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| A | ALA12 | |
| B | PRO251 | |
| B | LEU288 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | GLY25 | |
| B | GLY283 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| A | HIS103 | |
| A | LEU125 | |
| A | VAL132 | |
| A | LYS139 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| A | LEU109 | |
| A | VAL135 | |
| A | SER138 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| A | THR8 | |
| A | VAL17 | |
| A | THR41 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| A | VAL62 | |
| B | VAL218 | |
| B | VAL267 | |
| B | GLU321 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | TYR345 |
