1IO4
CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN-CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0005634 | cellular_component | nucleus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE AU C 200 |
| Chain | Residue |
| C | CYS81 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU D 200 |
| Chain | Residue |
| D | GLU24 |
| D | CYS124 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU D 201 |
| Chain | Residue |
| D | GLN45 |
| D | CYS48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000255 |
| Chain | Residue | Details |
| D | SER10 | |
| C | GLU116 | |
| C | ARG139 | |
| C | VAL170 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCA => ECO:0000305|PubMed:9374525 |
| Chain | Residue | Details |
| A | SER288 | |
| B | SER288 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CaMK2 => ECO:0000250|UniProtKB:P28033 |
| Chain | Residue | Details |
| A | SER325 | |
| B | SER325 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS260 | |
| B | LYS260 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS262 | |
| A | LYS332 | |
| B | LYS262 | |
| B | LYS332 |
