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1IM3

Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
F0000139cellular_componentGolgi membrane
F0001913biological_processT cell mediated cytotoxicity
F0001916biological_processpositive regulation of T cell mediated cytotoxicity
F0002237biological_processresponse to molecule of bacterial origin
F0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
F0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F0002502biological_processpeptide antigen assembly with MHC class I protein complex
F0002503biological_processpeptide antigen assembly with MHC class II protein complex
F0002726biological_processpositive regulation of T cell cytokine production
F0005198molecular_functionstructural molecule activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005765cellular_componentlysosomal membrane
F0005783cellular_componentendoplasmic reticulum
F0005788cellular_componentendoplasmic reticulum lumen
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006826biological_processiron ion transport
F0006879biological_processintracellular iron ion homeostasis
F0006955biological_processimmune response
F0007608biological_processsensory perception of smell
F0007611biological_processlearning or memory
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0010977biological_processnegative regulation of neuron projection development
F0012507cellular_componentER to Golgi transport vesicle membrane
F0016020cellular_componentmembrane
F0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
F0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
F0023026molecular_functionMHC class II protein complex binding
F0030670cellular_componentphagocytic vesicle membrane
F0031901cellular_componentearly endosome membrane
F0031902cellular_componentlate endosome membrane
F0031905cellular_componentearly endosome lumen
F0032092biological_processpositive regulation of protein binding
F0033077biological_processT cell differentiation in thymus
F0034756biological_processregulation of iron ion transport
F0035580cellular_componentspecific granule lumen
F0042026biological_processprotein refolding
F0042605molecular_functionpeptide antigen binding
F0042612cellular_componentMHC class I protein complex
F0042613cellular_componentMHC class II protein complex
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042824cellular_componentMHC class I peptide loading complex
F0045646biological_processregulation of erythrocyte differentiation
F0048260biological_processpositive regulation of receptor-mediated endocytosis
F0050680biological_processnegative regulation of epithelial cell proliferation
F0050768biological_processnegative regulation of neurogenesis
F0050778biological_processpositive regulation of immune response
F0050870biological_processpositive regulation of T cell activation
F0051289biological_processprotein homotetramerization
F0055038cellular_componentrecycling endosome membrane
F0060586biological_processmulticellular organismal-level iron ion homeostasis
F0070062cellular_componentextracellular exosome
F0071281biological_processcellular response to iron ion
F0071283biological_processcellular response to iron(III) ion
F0071316biological_processcellular response to nicotine
F1900121biological_processnegative regulation of receptor binding
F1900122biological_processpositive regulation of receptor binding
F1904434biological_processpositive regulation of ferrous iron binding
F1904437biological_processpositive regulation of transferrin receptor binding
F1904724cellular_componenttertiary granule lumen
F1990000biological_processamyloid fibril formation
F1990712cellular_componentHFE-transferrin receptor complex
F2000774biological_processpositive regulation of cellular senescence
F2000978biological_processnegative regulation of forebrain neuron differentiation
J0000139cellular_componentGolgi membrane
J0001913biological_processT cell mediated cytotoxicity
J0001916biological_processpositive regulation of T cell mediated cytotoxicity
J0002237biological_processresponse to molecule of bacterial origin
J0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
J0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
J0002502biological_processpeptide antigen assembly with MHC class I protein complex
J0002503biological_processpeptide antigen assembly with MHC class II protein complex
J0002726biological_processpositive regulation of T cell cytokine production
J0005198molecular_functionstructural molecule activity
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005765cellular_componentlysosomal membrane
J0005783cellular_componentendoplasmic reticulum
J0005788cellular_componentendoplasmic reticulum lumen
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0005925cellular_componentfocal adhesion
J0006826biological_processiron ion transport
J0006879biological_processintracellular iron ion homeostasis
J0006955biological_processimmune response
J0007608biological_processsensory perception of smell
J0007611biological_processlearning or memory
J0009897cellular_componentexternal side of plasma membrane
J0009986cellular_componentcell surface
J0010977biological_processnegative regulation of neuron projection development
J0012507cellular_componentER to Golgi transport vesicle membrane
J0016020cellular_componentmembrane
J0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
J0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
J0023026molecular_functionMHC class II protein complex binding
J0030670cellular_componentphagocytic vesicle membrane
J0031901cellular_componentearly endosome membrane
J0031902cellular_componentlate endosome membrane
J0031905cellular_componentearly endosome lumen
J0032092biological_processpositive regulation of protein binding
J0033077biological_processT cell differentiation in thymus
J0034756biological_processregulation of iron ion transport
J0035580cellular_componentspecific granule lumen
J0042026biological_processprotein refolding
J0042605molecular_functionpeptide antigen binding
J0042612cellular_componentMHC class I protein complex
J0042613cellular_componentMHC class II protein complex
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0042824cellular_componentMHC class I peptide loading complex
J0045646biological_processregulation of erythrocyte differentiation
J0048260biological_processpositive regulation of receptor-mediated endocytosis
J0050680biological_processnegative regulation of epithelial cell proliferation
J0050768biological_processnegative regulation of neurogenesis
J0050778biological_processpositive regulation of immune response
J0050870biological_processpositive regulation of T cell activation
J0051289biological_processprotein homotetramerization
J0055038cellular_componentrecycling endosome membrane
J0060586biological_processmulticellular organismal-level iron ion homeostasis
J0070062cellular_componentextracellular exosome
J0071281biological_processcellular response to iron ion
J0071283biological_processcellular response to iron(III) ion
J0071316biological_processcellular response to nicotine
J1900121biological_processnegative regulation of receptor binding
J1900122biological_processpositive regulation of receptor binding
J1904434biological_processpositive regulation of ferrous iron binding
J1904437biological_processpositive regulation of transferrin receptor binding
J1904724cellular_componenttertiary granule lumen
J1990000biological_processamyloid fibril formation
J1990712cellular_componentHFE-transferrin receptor complex
J2000774biological_processpositive regulation of cellular senescence
J2000978biological_processnegative regulation of forebrain neuron differentiation
N0000139cellular_componentGolgi membrane
N0001913biological_processT cell mediated cytotoxicity
N0001916biological_processpositive regulation of T cell mediated cytotoxicity
N0002237biological_processresponse to molecule of bacterial origin
N0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
N0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
N0002502biological_processpeptide antigen assembly with MHC class I protein complex
N0002503biological_processpeptide antigen assembly with MHC class II protein complex
N0002726biological_processpositive regulation of T cell cytokine production
N0005198molecular_functionstructural molecule activity
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005615cellular_componentextracellular space
N0005765cellular_componentlysosomal membrane
N0005783cellular_componentendoplasmic reticulum
N0005788cellular_componentendoplasmic reticulum lumen
N0005794cellular_componentGolgi apparatus
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0005925cellular_componentfocal adhesion
N0006826biological_processiron ion transport
N0006879biological_processintracellular iron ion homeostasis
N0006955biological_processimmune response
N0007608biological_processsensory perception of smell
N0007611biological_processlearning or memory
N0009897cellular_componentexternal side of plasma membrane
N0009986cellular_componentcell surface
N0010977biological_processnegative regulation of neuron projection development
N0012507cellular_componentER to Golgi transport vesicle membrane
N0016020cellular_componentmembrane
N0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
N0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
N0023026molecular_functionMHC class II protein complex binding
N0030670cellular_componentphagocytic vesicle membrane
N0031901cellular_componentearly endosome membrane
N0031902cellular_componentlate endosome membrane
N0031905cellular_componentearly endosome lumen
N0032092biological_processpositive regulation of protein binding
N0033077biological_processT cell differentiation in thymus
N0034756biological_processregulation of iron ion transport
N0035580cellular_componentspecific granule lumen
N0042026biological_processprotein refolding
N0042605molecular_functionpeptide antigen binding
N0042612cellular_componentMHC class I protein complex
N0042613cellular_componentMHC class II protein complex
N0042802molecular_functionidentical protein binding
N0042803molecular_functionprotein homodimerization activity
N0042824cellular_componentMHC class I peptide loading complex
N0045646biological_processregulation of erythrocyte differentiation
N0048260biological_processpositive regulation of receptor-mediated endocytosis
N0050680biological_processnegative regulation of epithelial cell proliferation
N0050768biological_processnegative regulation of neurogenesis
N0050778biological_processpositive regulation of immune response
N0050870biological_processpositive regulation of T cell activation
N0051289biological_processprotein homotetramerization
N0055038cellular_componentrecycling endosome membrane
N0060586biological_processmulticellular organismal-level iron ion homeostasis
N0070062cellular_componentextracellular exosome
N0071281biological_processcellular response to iron ion
N0071283biological_processcellular response to iron(III) ion
N0071316biological_processcellular response to nicotine
N1900121biological_processnegative regulation of receptor binding
N1900122biological_processpositive regulation of receptor binding
N1904434biological_processpositive regulation of ferrous iron binding
N1904437biological_processpositive regulation of transferrin receptor binding
N1904724cellular_componenttertiary granule lumen
N1990000biological_processamyloid fibril formation
N1990712cellular_componentHFE-transferrin receptor complex
N2000774biological_processpositive regulation of cellular senescence
N2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
BTYR78-HIS84
ATYR257-HIS263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000305|PubMed:11790769
ChainResidueDetails
DASN68
ETHR143
ELYS146
ETYR171
ITYR7
ITHR73
ITYR84
ITHR143
ILYS146
ITYR171
MTYR7
HASN68
MTHR73
MTYR84
MTHR143
MLYS146
MTYR171
LASN68
PASN68
ALYS146
ATYR171
ETYR7
ETHR73
ETYR84

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
BILE1
FILE1
JILE1
NILE1
ITYR116
ITYR159
MTYR116
MTYR159

site_idSWS_FT_FI3
Number of Residues24
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
BLYS19
FLYS58
FLYS91
FLYS94
JLYS19
JLYS41
JLYS48
JLYS58
JLYS91
JLYS94
NLYS19
BLYS41
NLYS41
NLYS48
NLYS58
NLYS91
NLYS94
BLYS48
BLYS58
BLYS91
BLYS94
FLYS19
FLYS41
FLYS48

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN86
EASN86
IASN86
MASN86

222415

PDB entries from 2024-07-10

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